Publication Name	World Journal of Gastroenterology
Manuscript ID	30681
Country	Taiwan

Received	2016-10-13 10:21
Peer-Review Started	2016-10-14 08:03
To Make the First Decision	2016-12-01 15:40
Return for Revision	2016-12-02 17:15
Revised	2016-12-15 23:31
Second Decision	2016-12-29 10:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-01-04 16:30
Articles in Press	2017-01-04 16:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-01-09 05:55
Typeset the Manuscript	2017-01-13 12:31
Publish the Manuscript Online	2017-01-22 11:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Ai-Ru Hsieh, Cathy SJ Fann, Chau-Ting Yeh, Hung-Chun Lin, Shy-Yi Wan, Yi-Cheng Chen, Chia-Lin Hsu, Jennifer Tai, Shi-Ming Lin and Dar-In Tai
Funding Agency and Grant Number	Funding Agency Grant Number Chang Gung Memorial Hospital CMRPG3C0701 the National Science Council NSC101-2314-B-182A-025-MY3 China Medical University CMU103-N-15
Corresponding Author	Dar-In Tai, MD, Professor, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No 5, FuXing Street, Guishan Dist., Taoyuan 333, Taiwan. tai48978@cgmh.org.tw
Key Words	Familial generation; Sex; Hepatitis B virus; Perinatal infection; Viral replication
Core Tip	Familial clustering of chronic hepatitis B infection is identified in this study. Most of the hepatitis B surface antigen (HBsAg) carriers in this cohort are in families of an HBsAg-positive index case. A high prevalence of HBsAg is found in the siblings’ generation and in offspring of an HBsAg-positive mother. The HBsAg status of index cases and HBsAg status of the mother are important factors for determining the persistence of hepatitis B virus (HBV) infection in hepatocellular carcinoma families. Sex and generation are factors associated with HBV replication. Perinatal infection has a great influence on male offspring’s HBV replication.
Publish Date	2017-01-22 11:39
Citation	Hsieh AR, Fann CSJ, Yeh CT, Lin HC, Wan SY, Chen YC, Hsu CL, Tai J, Lin SM, Tai DI. Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma. World J Gastroenterol 2017; 23(5): 876-884
URL	http://www.wjgnet.com/1007-9327/full/v23/i5/876.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i5.876

Full Article (PDF)	WJG-23-876.pdf
Full Article (Word)	WJG-23-876.doc
Manuscript File	30681-Review.docx
Answering Reviewers	30681-Answering reviewers.pdf
Audio Core Tip	30681-Audio core tip.mp3
Biostatistics Review Certificate	30681-Biostatistics statement.pdf
Clinical Trial Registration Statement	30681-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	30681-Conflict-of-interest statement.pdf
Copyright License Agreement	30681-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	30681-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	30681-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	30681-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	30681-Language certificate.pdf
Peer-review Report	30681-Peer-review(s).pdf
Scientific Misconduct Check	30681-Scientific misconduct check.pdf
Scientific Editor Work List	30681-Scientific editor work list.pdf