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2/20/2017 5:58:00 PM | Browse: 328 | Download: 469
Publication Name World Journal of Gastroenterology
Manuscript ID 30766
Country/Territory Italy
Received
2016-10-16 08:35
Peer-Review Started
2016-10-31 17:10
To Make the First Decision
2016-12-19 09:50
Return for Revision
2016-12-20 21:30
Revised
2016-12-29 08:09
Second Decision
2017-01-16 11:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-01-18 16:18
Articles in Press
2017-01-18 16:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-02-07 14:58
Publish the Manuscript Online
2017-02-20 17:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms
Manuscript Source Invited Conference Manuscripts
All Author List Francesca Romana Ponziani, Maurizio Pompili, Enrico Di Stasio, Maria Assunta Zocco, Antonio Gasbarrini and Roberto Flore
Funding Agency and Grant Number
Corresponding author Francesca Romana Ponziani, MD, Internal Medicine, Gastroenterology and Hepatology, Agostino Gemelli Hospital, Largo Agostino Gemelli 8, 00168 Rome, Italy. francesca.ponziani@yahoo.it
Keywords small intestinal bacterial overgrowth; vitamin K; dysbiosis; atherosclerosis; cardiovascular disease risk
Core Tip The matrix Gla-protein is involved in maintaining vascular health and vitamin K2 is a prerequisite for its activation and function. Intestinal bacteria are the main source of vitamin K2 in humans and small intestinal bacterial overgrowth (SIBO) is associated with altered vitamin K2 metabolism. This study demonstrates that SIBO is associated with increased plasma levels of inactive matrix Gla-protein, which, in turn, correlates directly with early markers of atherosclerotic disease such as increased arterial stiffness. Therefore, SIBO has the potential to serve as an indicator for increased risk of developing an overt cardiovascular disease.
Publish Date 2017-02-20 17:58
Citation Ponziani FR, Pompili M, Di Stasio E, Zocco MA, Gasbarrini A, Flore R. Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms. World J Gastroenterol 2017; 23(7): 1241-1249
Url http://www.wjgnet.com/1007-9327/full/v23/i7/1241.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i7.1241
Full Article (PDF) WJG-23-1241.pdf
Full Article (Word) WJG-23-1241.doc
Manuscript File 30766-Review.docx
Answering Reviewers 30766-Aswering reviewers.pdf
Audio Core Tip 30766-Audio core tip.mp3
Biostatistics Review Certificate 30766-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 30766-Conflict-of-interest statement.pdf
Copyright License Agreement 30766-Copyright assignment.pdf
Data Sharing Statement 30766-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 30766-Institutional review board statement.pdf
Scientific Research Process 30766-Scientific research process.pdf
Supplementary Material 30766-Supplementary material.pdf
Peer-review Report 30766-Peer-review(s).pdf
Scientific Misconduct Check 30766-Scientific misconduct check.pdf
Scientific Editor Work List 30766-Scientific editor work list.pdf