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Articles Published Processes
5/4/2017 8:16:34 AM | Browse: 1290 | Download: 2490
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Received |
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2016-10-17 10:02 |
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Peer-Review Started |
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2016-10-19 14:34 |
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To Make the First Decision |
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2016-12-27 18:26 |
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Return for Revision |
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2016-12-29 12:08 |
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Revised |
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2017-01-05 22:03 |
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Second Decision |
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2017-03-02 16:13 |
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Accepted by Journal Editor-in-Chief |
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2017-03-02 20:46 |
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Accepted by Executive Editor-in-Chief |
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2017-03-13 11:30 |
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Articles in Press |
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2017-03-13 11:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-28 10:06 |
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Publish the Manuscript Online |
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2017-05-04 08:16 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Saurabh Kedia, Vikram Bhatia, Sandeep Thareja, Sushil Garg, Venigalla Pratap Mouli, Sawan Bopanna, Veena Tiwari, Govind Makharia and Vineet Ahuja |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Vineet Ahuja, Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Room No. 3093, Third Floor, Teaching Block, AIIMS, New Delhi 110029, India. vins_ahuja@hotmail.com |
| Key Words |
Curcumin; Mesalamine; Ulcerative colitis; Ulcerative colitis disease activity index; Mucosal healing |
| Core Tip |
Not all patients with mild to moderate ulcerative colitis (UC) respond to available treatment options. Curcumin, an active ingredient of turmeric has anti-inflammatory properties and has been shown to play a protective role in chemically induced mouse models of inflammatory bowel disease and to reduce relapse rates in human UC. However, optimum dose ranging studies for curcumin in ulcerative colitis have not been performed. The present study shows that low dose curcumin (450 mg/d) is ineffective in inducing remission in mild to moderate ulcerative colitis. Therefore, higher doses with effective modes of delivery are required for optimal efficacy of curcumin. |
| Publish Date |
2017-05-04 08:16 |
| Citation |
Kedia S, Bhatia V, Thareja S, Garg S, Mouli VP, Bopanna S, Tiwari V, Makharia G, Ahuja V. Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial. World J Gastrointest Pharmacol Ther 2017; 8(2): 147-154 |
| URL |
http://www.wjgnet.com/2150-5349/full/v8/i2/147.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v8.i2.147 |
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