Publication Name	World Journal of Gastroenterology
Manuscript ID	30858
Country	United States

Received	2016-10-20 09:08
Peer-Review Started	2016-10-21 09:15
To Make the First Decision	2016-11-09 08:31
Return for Revision	2016-11-09 10:14
Revised	2016-11-10 08:42
Second Decision	2016-11-17 16:18
Accepted by Journal Editor-in-Chief	2016-11-17 19:51
Accepted by Executive Editor-in-Chief	2016-11-28 18:07
Articles in Press	2016-11-28 18:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-02 22:17
Publish the Manuscript Online	2016-12-13 00:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective
Manuscript Source	Invited Manuscript
All Author List	Jordan E Axelrad, Abhik Roy, Garrett Lawlor, Burton Korelitz and Simon Lichtiger
Funding Agency and Grant Number
Corresponding Author	Jordan E Axelrad, MD, MPH, Department of Medicine, Division of Digestive and Liver Diseases, Columbia University Medical Center, 630 West 168th Street, Box 83, Presbyterian Hospital 7 West, Room 318, New York, NY 10032, United States. ja3064@cumc.columbia.edu
Key Words	Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Thiopurines; Mercaptopurine; Azathioprine
Core Tip	In this review, we systematically describe the historical and current evidence in the use of thiopurines in inflammatory bowel disease (IBD). The most robust evidence for thiopurines in IBD includes induction of remission in combination with anti-tumor necrosis factor agents, and maintenance of remission and post-operative maintenance in Crohn’s disease. With more effective and newer therapeutic agents, the positioning of thiopurines in the management of IBD will change. Future studies should examine the benefit of thiopurines alone and in conjunction with these novel agents.
Publish Date	2016-12-13 00:40
Citation	Axelrad JE, Roy A, Lawlor G, Korelitz B, Lichtiger S. Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective. World J Gastroenterol 2016; 22(46): 10103-10117
URL	http://www.wjgnet.com/1007-9327/full/v22/i46/10103.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i46.10103

Full Article (PDF)	WJG-22-10103.pdf
Full Article (Word)	WJG-22-10103.doc
Manuscript File	30858-Review.docx
Answering Reviewers	30858-Answering reviewers.pdf
Audio Core Tip	30858-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	30858-Conflict-of-interest statement.pdf
Copyright License Agreement	30858-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20161020050026.doc
Peer-review Report	30858-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	30858-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	30858-Scientific misconduct check.pdf
Scientific Editor Work List	30858-Scientific editor work list.pdf