Publication Name	World Journal of Gastroenterology
Manuscript ID	31069
Country	Australia

Received	2016-10-28 10:24
Peer-Review Started	2016-10-29 20:44
To Make the First Decision	2016-12-19 09:51
Return for Revision	2016-12-24 16:46
Revised	2017-01-20 07:48
Second Decision	2017-03-09 13:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-15 12:11
Articles in Press	2017-03-15 12:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-23 10:12
Publish the Manuscript Online	2017-04-06 18:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
Manuscript Source	Invited Manuscript
All Author List	Chandra Diwakarla, Katherine Hannan, Nadine Hein and Desmond Yip
Funding Agency and Grant Number
Corresponding Author	Chandra Diwakarla, BSc(Hons), MBBS, Oncology Fellow, Department of Medical Oncology, The Canberra Hospital, Yamba Drive, Woden ACT 2605, Australia. chandra.diwakarla@anu.edu.au
Key Words	Ribosome biogenesis; Nucleolar stress; RNA polymerase I; Pancreatic ductal adenocarcinoma; Chemotherapy
Core Tip	This manuscript is a review of the complexities involved in the treatment of advanced pancreatic ductal adenocarcinoma. It details the current approaches to therapy and the disease factors which have impacted on progress thus far. This review identifies the possible role of nucleolar stress as a treatment modality based on recent data from studies of haematological ma­lignancies and some other solid organ cancers and explains the basic science involved in this process.
Publish Date	2017-04-06 18:30
Citation	Diwakarla C, Hannan K, Hein N, Yip D. Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options. World J Gastroenterol 2017; 23(13): 2276-2285
URL	http://www.wjgnet.com/1007-9327/full/v23/i13/2276.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i13.2276

Full Article (PDF)	WJG-23-2276.pdf
Full Article (Word)	WJG-23-2276.doc
Manuscript File	31069-Review.docx
Answering Reviewers	31069-Answering reviewers.pdf
Audio Core Tip	31069-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31069-Conflict-of-interest statement.pdf
Copyright License Agreement	31069-Copyright assignment.pdf
Peer-review Report	31069-Peer-review(s).pdf
Scientific Misconduct Check	31069-Scientific misconduct check.pdf
Scientific Editor Work List	31069-Scientific editor work list.pdf