Publication Name	World Journal of Gastroenterology
Manuscript ID	31218
Country	Spain

Received	2016-11-05 12:15
Peer-Review Started	2016-11-21 16:51
First Decision by Editorial Office Director
Return for Revision	2017-01-03 14:52
Revised	2017-03-03 00:00
Publication Fee Transferred	2017-04-07 17:30
Second Decision by Editor	2017-03-09 17:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-03-15 13:33
Articles in Press	2017-03-15 13:34
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-25 09:18
Publish the Manuscript Online	2017-05-06 20:30

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Cost-effectiveness of enhanced liver fibrosis test to assess liver fibrosis in chronic hepatitis C virus and alcoholic liver disease patients
Manuscript Source	Unsolicited Manuscript
All Author List	Marcelo Soto, Laura Sampietro-Colom, Luis Lasalvia, Aurea Mira, Wladimiro Jiménez and Miquel Navasa
Funding Agency and Grant Number	Funding Agency Grant Number Siemens. Marcelo Soto received financial support from Plataforma ITEMAS PT13/0006/0009 (FCRB PI043029, partially)
Corresponding Author	Dr. Marcelo Soto, Fundació Clínic per a la Recerca Biomèdica, Roselló 149-153, 08036 Barcelona, Spain. soto@clinic.ub.es
Key Words	Cost-effectiveness analysis; Liver fibrosis; Noninvasive diagnostic assessment; Alcoholic liver disease; Hepatitis C
Core Tip	Noninvasive methods to diagnose liver fibrosis have been proposed as an alternative to liver biopsy in patients with abnormal level of transaminases. In a Markov model, sequential testing with enhanced liver fibrosis (ELF) test followed by liver stiffness measurement (LSM) significantly reduce liver-related lifetime morbidity and mortality, compared with biopsy, in hepatitis C virus (HCV) and alcoholic liver disease patients. Noninvasive methods are also associated with an increase in quality-adjusted life years and costs. Overall, they are cost-effective strategies compared with biopsy. ELF test with or without a confirmation LSM may represent a more affordable strategy than the “treat-all” option in HCV patients.
Publish Date	2017-05-06 20:30
Citation	Soto M, Sampietro-Colom L, Lasalvia L, Mira A, Jiménez W, Navasa M. Cost-effectiveness of enhanced liver fibrosis test to assess liver fibrosis in chronic hepatitis C virus and alcoholic liver disease patients. World J Gastroenterol 2017; 23(17): 3163-3173
URL	http://www.wjgnet.com/1007-9327/full/v23/i17/3163.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i17.3163

Full Article (PDF)	WJG-23-3163.pdf
Full Article (Word)	WJG-23-3163.doc
Manuscript File	31218-Review.docx
Answering Reviewers	31218-Answering reviewers.pdf
Audio Core Tip	31218-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	31218-Conflict-of-interest statement.pdf
Copyright License Agreement	31218-Copyright assignment.pdf
Supplementary Material	31218-Supplementary material.docx
Peer-review Report	31218-Peer-review(s).pdf
Scientific Misconduct Check	31218-Scientific misconduct check.pdf
Scientific Editor Work List	31218-Scientific editor work list.pdf