Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	31615
Country	Greece

Received	2016-11-28 10:21
Peer-Review Started
To Make the First Decision	2016-12-01 14:13
Return for Revision	2016-12-07 10:14
Revised	2016-12-28 10:25
Second Decision	2017-03-02 16:16
Accepted by Journal Editor-in-Chief	2017-03-02 20:05
Accepted by Company Editor-in-Chief	2017-03-13 11:34
Articles in Press	2017-03-13 11:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-30 14:41
Publish the Manuscript Online	2017-04-10 15:59

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Abnormal DNA methylation as a cell-free circulating DNA biomarker for colorectal cancer detection: A review of literature
Manuscript Source	Invited Manuscript
All Author List	Michail Galanopoulos, Nikolaos Tsoukalas, Ioannis S Papanikolaou, Maria Tolia, Maria Gazouli and Gerassimos J Mantzaris
Funding Agency and Grant Number
Corresponding Author	Nikolaos Tsoukalas, MD, MSc, PhD, Medical Oncologist, MSc in Bioinformatics, Department of Medical Oncology, Veterans Hospital (417 NIMTS), Gennimata N. 10-12 Ampelokipi, GR 11524 Athens, Greece. tsoukn@yahoo.gr
Key Words	Colorectal cancer early detection; Colorectal cancer screening; Circulating free DNA; Colorectal cancer blood-based biomarkers; DNA methylation blood biomarkers
Core Tip	Colorectal cancer (CRC) is one of the most prevalent malignancies in the world. CRC-associated morbidity and mortality is continuously increasing, in part due to a lack of early detection. The main aim of this article is the brief description of the basic screening modalities and their efficacy for CRC detection, the process of colorectal carcinogenesis and how the molecular pathways of CRC (focusing on epigenetic modifications) influence the clinical application of new blood-based biomarkers such as circDNA. Then we will focus on the most recent findings concerning the studies on circDNA, mainly related to DNA methylation and the challenges for validation and globally implementation of this emergent technology.
Publish Date	2017-04-10 15:59
Citation	Galanopoulos M, Tsoukalas N, Papanikolaou IS, Tolia M, Gazouli M, Mantzaris GJ. Abnormal DNA methylation as a cell-free circulating DNA biomarker for colorectal cancer detection: A review of literature. World J Gastrointest Oncol 2017; 9(4): 142-152
URL	http://www.wjgnet.com/1948-5204/full/v9/i4/142.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i4.142

Full Article (PDF)	WJGO-9-142.pdf
Full Article (Word)	WJGO-9-142.doc
Manuscript File	31615-Review.docx
Answering Reviewers	31615-Answering reviewers.pdf
Audio Core Tip	31615-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	31615-Conflict-of-interest statement.pdf
Copyright License Agreement	31615-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20161128085251.doc
Peer-review Report	31615-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31615-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31615-Scientific misconduct check.pdf
Scientific Editor Work List	31615-Scientific editor work list.pdf