Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	31764
Country	Spain

Received	2016-12-06 09:24
Peer-Review Started	2016-12-07 07:53
First Decision by Editorial Office Director
Return for Revision	2017-01-16 19:03
Revised	2017-01-18 20:19
Publication Fee Transferred
Second Decision by Editor	2017-02-20 16:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-03-02 08:38
Articles in Press	2017-03-02 08:38
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-13 18:07
Publish the Manuscript Online	2017-05-16 06:56

ISSN	2150-5330 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Embrionary way to create a fatty liver in portal hypertension
Manuscript Source	Invited Manuscript
All Author List	Maria-Angeles Aller, Natalia Arias, Isabel Peral, Sara García-Higarza, Jorge-Luis Arias and Jaime Arias
Funding Agency and Grant Number	Funding Agency Grant Number FICYT FC-15-GRUPIN 14-088 Alfonso Martin Escudero Foundation
Corresponding Author	Maria-Angeles Aller, MD, PhD, Department of Surgery, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n., 28040 Madrid, Spain. maaller@med.ucm.es
Key Words	Inflammation; Non-alcoholic fatty liver disease; Hepatic steatosis; Extraembryonic functions; Fibrosis; Portal hypertension
Core Tip	The current hypothesis proposes that the re-expression of two embryonic systemic functional axes in the rat after partial portal vein ligation produces a non-alcoholic fatty liver disease. These axes, a coelomicamniotic axis and a trophoblastic yolk-sac or vitelline axis, would then integrate in the interstitial liver space of Disse. If so, these recapitulated embryonic functions would produce firstly, the evolution of liver steatosis. In this way, this fat liver could represent a yolk-saclike in portal hypertensive rats. After that, these embryonic functions would induce a gastrulation-like response in which liver fibrosis occcur. For that reason, studying the mechanisms involved in embryonic development could provide key results for a better understanding of the non-alcoholic fatty liver disease pathophysiology.
Publish Date	2017-05-16 06:56
Citation	Aller MA, Arias N, Peral I, García-Higarza S, Arias JL, Arias J. Embrionary way to create a fatty liver in portal hypertension. World J Gastrointest Pathophysiol 2017; 8(2): 39-50
URL	http://www.wjgnet.com/2150-5330/full/v8/i2/39.htm
DOI	http://dx.doi.org/10.4291/wjgp.v8.i2.39

Full Article (PDF)	WJGP-8-39.pdf
Full Article (Word)	WJGP-8-39.doc