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Articles Published Processes
5/16/2017 6:56:36 AM | Browse: 1357 | Download: 2253
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Received |
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2016-12-06 09:24 |
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Peer-Review Started |
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2016-12-07 07:53 |
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To Make the First Decision |
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2017-01-14 11:20 |
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Return for Revision |
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2017-01-16 19:03 |
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Revised |
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2017-01-18 20:19 |
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Second Decision |
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2017-02-20 16:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-02 08:38 |
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Articles in Press |
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2017-03-02 08:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-05-13 18:07 |
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Publish the Manuscript Online |
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2017-05-16 06:56 |
| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Embrionary way to create a fatty liver in portal hypertension
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maria-Angeles Aller, Natalia Arias, Isabel Peral, Sara García-Higarza, Jorge-Luis Arias and Jaime Arias |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FICYT FC-15-GRUPIN 14-088 |
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| Alfonso Martin Escudero Foundation |
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| Corresponding Author |
Maria-Angeles Aller, MD, PhD, Department of Surgery, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n., 28040 Madrid, Spain. maaller@med.ucm.es |
| Key Words |
Inflammation; Non-alcoholic fatty liver disease; Hepatic steatosis; Extraembryonic functions; Fibrosis; Portal hypertension |
| Core Tip |
The current hypothesis proposes that the re-expression of two embryonic systemic functional axes in the rat after partial portal vein ligation produces a non-alcoholic fatty liver disease. These axes, a coelomicamniotic axis and a trophoblastic yolk-sac or vitelline axis, would then integrate in the interstitial liver space of Disse. If so, these recapitulated embryonic functions would produce firstly, the evolution of liver steatosis. In this way, this fat liver could represent a yolk-saclike in portal hypertensive rats. After that, these embryonic functions would induce a gastrulation-like response in which liver fibrosis occcur. For that reason, studying the mechanisms involved in embryonic development could provide key results for a better understanding of the non-alcoholic fatty liver disease pathophysiology. |
| Publish Date |
2017-05-16 06:56 |
| Citation |
Aller MA, Arias N, Peral I, García-Higarza S, Arias JL, Arias J. Embrionary way to create a fatty liver in portal hypertension. World J Gastrointest Pathophysiol 2017; 8(2): 39-50 |
| URL |
http://www.wjgnet.com/2150-5330/full/v8/i2/39.htm |
| DOI |
http://dx.doi.org/10.4291/wjgp.v8.i2.39 |
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