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5/15/2017 6:16:31 AM | Browse: 412 | Download: 485
Publication Name World Journal of Gastroenterology
Manuscript ID 31928
Country/Territory United States
2016-12-15 15:19
Peer-Review Started
2016-12-17 20:12
To Make the First Decision
2016-12-29 08:54
Return for Revision
2017-01-04 20:19
2017-01-27 01:13
Second Decision
2017-03-09 13:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-15 12:14
Articles in Press
2017-03-15 12:14
Publication Fee Transferred
2017-04-14 13:34
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-04-25 18:26
Publish the Manuscript Online
2017-05-15 06:16
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease
Manuscript Source Unsolicited Manuscript
All Author List James D Lord and Donna M Shows
Funding Agency and Grant Number
Funding Agency Grant Number
Virginia Mason Medical Center, Digestive Disease Institute Research Grant Award 0506812-2011
Corresponding author James D Lord, MD, PhD, Research Assistant Member, Translational Research Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, United States. jlord@benaroyaresearch.org
Keywords Thiopurine; Azathioprine; Mercaptopurine; Lymphocyte; Natural killer cell; Transitional B cell; Inflammatory bowel disease
Core Tip Thiopurine medications have been used to treat inflammatory bowel disease (IBD) for almost half a century. However, the effect of thiopurines on the human immune system in vitro remains unclear. The enclosed manuscript performed a thorough flow cytometric analysis of peripheral blood specimens from IBD patients with or without thiopurine therapy and found significant differences in B and NK cell populations associated with therapy. These suggest that thiopurines function to suppress inflammation in IBD not by causing T cell apoptosis, as had been suggested by in vitro data, but rather by depleting other lymphocytes.
Publish Date 2017-05-15 06:16
Citation Lord JD, Shows DM. Thiopurine use associated with reduced b and natural killer cells in inflammatory bowel disease. World J Gastroenterol 2017; 23(18): 3240-3251
Url http://www.wjgnet.com/1007-9327/full/v23/i18/3240.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i18.3240
Full Article (PDF) WJG-23-3240.pdf
Full Article (Word) WJG-23-3240.doc
Manuscript File 31928-Review.docx
Answering Reviewers 31928-Answering reviewers.pdf
Audio Core Tip 31928-Audio core tip.MP3
Biostatistics Review Certificate 31928-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 31928-Conflict-of-interest statement.pdf
Copyright License Agreement 31928-Copyright assignment.pdf
Data Sharing Statement 31928-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31928-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20161215074407.docx
Institutional Review Board Approval Form or Document 31928-Institutional review board statement.pdf
Scientific Research Process 31928-Scientific research process.pdf
Supplementary Material 31928-Supplementary material.pdf
Peer-review Report 31928-Peer-review(s).pdf
Scientific Misconduct Check 31928-Scientific misconduct check.pdf
Scientific Editor Work List 31928-Scientific editor work list.pdf