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Articles Published Processes
5/15/2017 6:16:31 AM | Browse: 1049 | Download: 1718
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Received |
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2016-12-15 15:19 |
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Peer-Review Started |
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2016-12-17 20:12 |
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To Make the First Decision |
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2016-12-29 08:54 |
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Return for Revision |
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2017-01-04 20:19 |
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Revised |
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2017-01-27 01:13 |
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Second Decision |
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2017-03-09 13:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-15 12:14 |
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Articles in Press |
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2017-03-15 12:14 |
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Publication Fee Transferred |
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2017-04-14 13:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-25 18:26 |
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Publish the Manuscript Online |
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2017-05-15 06:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
James D Lord and Donna M Shows |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Virginia Mason Medical Center, Digestive Disease Institute Research Grant Award |
0506812-2011 |
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| Corresponding Author |
James D Lord, MD, PhD, Research Assistant Member, Translational Research Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101, United States. jlord@benaroyaresearch.org |
| Key Words |
Thiopurine; Azathioprine; Mercaptopurine; Lymphocyte; Natural killer cell; Transitional B cell; Inflammatory bowel disease |
| Core Tip |
Thiopurine medications have been used to treat inflammatory bowel disease (IBD) for almost half a century. However, the effect of thiopurines on the human immune system in vitro remains unclear. The enclosed manuscript performed a thorough flow cytometric analysis of peripheral blood specimens from IBD patients with or without thiopurine therapy and found significant differences in B and NK cell populations associated with therapy. These suggest that thiopurines function to suppress inflammation in IBD not by causing T cell apoptosis, as had been suggested by in vitro data, but rather by depleting other lymphocytes. |
| Publish Date |
2017-05-15 06:16 |
| Citation |
Lord JD, Shows DM. Thiopurine use associated with reduced b and natural killer cells in inflammatory bowel disease. World J Gastroenterol 2017; 23(18): 3240-3251 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i18/3240.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i18.3240 |
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