Publication Name	World Journal of Gastroenterology
Manuscript ID	32029
Country	Australia

Received	2016-12-22 09:52
Peer-Review Started	2016-12-23 19:06
To Make the First Decision	2017-01-10 15:42
Return for Revision	2017-01-16 19:42
Revised	2017-01-27 11:35
Second Decision	2017-03-17 17:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-03-20 15:11
Articles in Press	2017-03-20 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-04-12 17:54
Publish the Manuscript Online	2017-04-20 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Age-related impairment of esophagogastric junction relaxation and bolus flow time
Manuscript Source	Invited Manuscript
All Author List	Charles Cock, Laura K Besanko, Carly M Burgstad, Alison Thompson, Stamatiki Kritas, Richard Heddle, Robert JL Fraser and Taher I Omari
Funding Agency and Grant Number
Corresponding Author	Dr. Charles Cock, FRACP, Director, Investigation and Procedures Unit, Repatriation General Hospital, Daws Road Rd, Daw Park, South Australia 5041, Australia. charles.cock@flinders.edu.au
Key Words	Aging; Esophagus; Impedance; Manometry; Pressure; Esophagogastric junction
Core Tip	Disturbances in esophagogastric junction (EGJ) relaxation have previously been described in extreme older age (> 80 years). The functional consequences of such observations are not known. We investigated several novel metrics of EGJ function - EGJ-contractile integral (EGJ-CI), “total” EGJ-CI during swallowing and EGJ bolus flow time - in young controls and asymptomatic healthy older volunteers (> 80 years). Our findings indicate reduced swallow-induced EGJ relaxation and decreased EGJ bolus flow in older subjects. These findings confirm functional consequences for observations such as increased IRP measurements in older subjects and that caution applies when interpreting EGJ metrics in older patients.
Publish Date	2017-04-20 15:58
Citation	Cock C, Besanko LK, Burgstad CM, Thompson A, Kritas S, Heddle R, Fraser RJL, Omari TI. Age-related impairment of esophagogastric junction relaxation and bolus flow time. World J Gastroenterol 2017; 23(15): 2785-2794
URL	http://www.wjgnet.com/1007-9327/full/v23/i15/2785.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i15.2785

Full Article (PDF)	WJG-23-2785.pdf
Full Article (Word)	WJG-23-2785.doc
Manuscript File	32029-Review.docx
Answering Reviewers	32029-Answering reviewers.pdf
Audio Core Tip	32029-Audio core tip.wav
Biostatistics Review Certificate	32029-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32029-Conflict-of-interest statement.pdf
Copyright License Agreement	32029-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161221193348.pdf
Institutional Review Board Approval Form or Document	32029-Institutional review board statement.pdf
Peer-review Report	32029-Peer-review(s).pdf
Scientific Misconduct Check	32029-Scientific misconduct check.pdf
Scientific Editor Work List	32029-Scientific editor work list.pdf