| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Public, Environmental & Occupational Health |
| Manuscript Type |
Case Control Study |
| Article Title |
Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yasushi Adachi, Masanori Nojima, Mitsuru Mori, Kentaro Yamashita, Hiro-o Yamano, Hiroshi Nakase, Takao Endo, Kenji Wakai, Kiyomi Sakata and Akiko Tamakoshi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Ministry of Education, Culture, Sports, Science, and Technology and from the Ministry of Health, Labour and Welfare, Japan |
|
|
| Corresponding Author |
Yasushi Adachi, MD, PhD, Department of Gastroenterology, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan. yadachi@sapmed.ac.jp |
| Key Words |
Esophageal cancer; Insulin-like growth factor; Insulin-like growth factor binding protein; Nested case-control study; Odds ratio |
| Core Tip |
Insulin-like growth factor-1 (IGF1) is a potent mitogen, whereas IGF-binding protein-3 (IGFBP3) binds and inhibits IGF1. High circulating IGF1 and low IGFBP3 are associated with increased risk of several cancers. Here we assessed the relationship between these molecules and the risk of esophageal carcinoma in a prospective, nested case-control study from the Japan Collaborative Cohort Study. Free IGF1, represented by the molar ratio of IGF1/IGFBP3, was not correlated with the risk of esophageal carcinoma. The free form of IGFBP3, which is estimated by the molar difference of IGFBP3-IGF1, may be inversely associated with esophageal cancer incidence. |
| Publish Date |
2017-05-20 12:26 |
| Citation |
Adachi Y, Nojima M, Mori M, Yamashita K, Yamano H, Nakase H, Endo T, Wakai K, Sakata K, Tamakoshi A. Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study. World J Gastroenterol 2017; 23(19): 3488-3495 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i19/3488.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i19.3488 |
