| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Veruska Cintia Alexandrino de Souza, Thiago Almeida Pereira, Valéria Wanderley Teixeira, Helotonio Carvalho, Maria Carolina Accioly Brelaz de Castro, Carolline Guimarães D’assunção, Andréia Ferreira de Barros, Camila Lima Carvalho, Virgínia Maria Barros de Lorena, Vláudia Maria Assis Costa, Álvaro Aguiar Coelho Teixeira, Regina Celia Bressan Queiroz Figueiredo and Sheilla Andrade de Oliveira |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council of Technological and Scientific Development (CNPq) |
APQ 0906-2.11/08 |
| Oswaldo Cruz Foundation (FIOCRUZ) |
|
| Pernambuco Science and Technology Support Foundation (FACEPE) |
|
| National Council for the Improvement of Higher Education (CAPES) |
|
| Intramural Research Program of the National Institutes of Health (LPD/NIAID/NIH) |
|
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| Corresponding Author |
Sheilla Andrade de Oliveira, PhD, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Av. Professor Moraes Rego s/n, Cidade Universitária, Recife, Pernambuco 50740-465, Brazil. sheilla@cpqam.fiocruz.br |
| Key Words |
Monocytes; Bone marrow mononuclear cells; Cell therapy; Macrophages; Glutathione; Liver fibrosis |
| Core Tip |
Chronic inflammation is now recognized as a central player in the development of liver fibrosis. Studies have shown that activated macrophages establish a link between chronic inflammation and fibrosis in various organs. The present study evaluated the therapeutic effects of bone marrow-derived CD11b+CD14+ monocytes in a murine model of liver damage. The results show that mice with transplants had improvement of liver fibrosis by way of a reduction in oxidative stress and inflammation and an increase in anti-fibrogenic factors. The study demonstrates the beneficial effects of cellular therapy in liver fibrosis and also reports on the important modulatory mechanisms involved. |
| Publish Date |
2017-07-28 08:16 |
| Citation |
de Souza VCA, Pereira TA, Teixeira VW, Carvalho H, de Castro MCAB, D’assunção CG, de Barros AF, Carvalho CL, de Lorena VMB, Costa VMA, Teixeira AAC, Figueiredo RCBQ, de Oliveira SA. Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress. World J Gastroenterol 2017; 23(28): 5146-5157 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i28/5146.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i28.5146 |
