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7/27/2017 1:36:42 AM | Browse: 519 | Download: 583
Publication Name World Journal of Immunology
Manuscript ID 32448
Country/Territory United States
Received
2017-01-09 09:07
Peer-Review Started
2017-01-12 09:01
To Make the First Decision
2017-02-15 09:55
Return for Revision
2017-02-16 14:12
Revised
2017-02-25 20:46
Second Decision
2017-03-13 11:01
Accepted by Journal Editor-in-Chief
2017-03-13 21:09
Accepted by Company Editor-in-Chief
2017-04-07 15:25
Articles in Press
2017-04-07 15:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-07-18 08:06
Publish the Manuscript Online
2017-07-27 01:36
ISSN 2219-2824 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Review
Article Title Holistic paradigm in carcinogenesis: Genetics, epigenetics, immunity, inflammation and oral infections
Manuscript Source Invited Manuscript
All Author List Sok-Ja Janket, Marium Qureshi, Antonio Bascones-Martinez, Jerian González-Febles and Jukka H Meurman
Funding Agency and Grant Number
Funding Agency Grant Number
Helsinki University Hospital funds (to Meurman JH) TYH2015323
Corresponding author Sok-Ja Janket, DMD, MPH, Department of Periodontology, Boston University H. M. Goldman School of Dental Medicine, 100 East Newton Street, Room B08A, Boston, MA 02118, United States. skjanket@bu.edu
Key Words Genetics; Carcinogenesis; Inflammation; Epigenetics; Immunity; Infections
Core Tip A recent debate among renowned scholars prompted us to review cancer pathogenesis in a holistic approach. One group attributed cancer to “random errors in DNA multiplication” (Tomasetti C, Science, 2015) while other experts credited environmental factors for cancer causation (Wu S, Nature, 2016). However, we put forward the concept that cancer is multifactorial and both intrinsic (DNA multiplication errors) and extrinsic (environmental) factors contribute to carcinogenesis. In this review, we examined these risk factors in some detail covering genetics, epigenetics, immunity, inflammation and infections. We acknowledge the contribution of each risk factor is different in various types of cancer. In some cancers, genetics plays a powerful role while in others, metabolism contributes a stronger impact. Therefore, a holistic understanding of carcinogenesis is truly necessary considering multi­system involvement in cancer development.
Publish Date 2017-07-27 01:36
Citation Janket SJ, Qureshi M, Bascones-Martinez A, González-Febles J, Meurman JH. Holistic paradigm in carcinogenesis: Genetics, epigenetics, immunity, inflammation and oral infections. World J Immunol 2017; 7(2): 11-23
Url http://www.wjgnet.com/2219-2824/full/v7/i2/11.htm
DOI http://dx.doi.org/10.5411/wji.v7.i2.11
Full Article (PDF) WJI-7-11.pdf
Full Article (Word) WJI-7-11.doc
Manuscript File 32448-Review.doc
Answering Reviewers 32448-Answering reviewers.pdf
Audio Core Tip 32448-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32448-Conflict-of-interest statement.pdf
Copyright License Agreement 32448-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32448-Grant application form(s).pdf
Supplementary Material 32448-Supplementary material.docx
Peer-review Report 32448-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 32448-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 32448-Scientific misconduct check.pdf
Scientific Editor Work List 32448-Scientific editor work list.pdf