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Articles Published Processes
7/27/2017 1:36:42 AM | Browse: 1335 | Download: 2179
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Received |
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2017-01-09 09:07 |
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Peer-Review Started |
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2017-01-12 09:01 |
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To Make the First Decision |
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2017-02-15 09:55 |
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Return for Revision |
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2017-02-16 14:12 |
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Revised |
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2017-02-25 20:46 |
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Second Decision |
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2017-03-13 11:01 |
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Accepted by Journal Editor-in-Chief |
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2017-03-13 21:09 |
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Accepted by Executive Editor-in-Chief |
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2017-04-07 15:25 |
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Articles in Press |
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2017-04-07 15:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-18 08:06 |
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Publish the Manuscript Online |
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2017-07-27 01:36 |
| ISSN |
2219-2824 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Holistic paradigm in carcinogenesis: Genetics, epigenetics, immunity, inflammation and oral infections
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sok-Ja Janket, Marium Qureshi, Antonio Bascones-Martinez, Jerian González-Febles and Jukka H Meurman |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Helsinki University Hospital funds (to Meurman JH) |
TYH2015323 |
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| Corresponding Author |
Sok-Ja Janket, DMD, MPH, Department of Periodontology, Boston University H. M. Goldman School of Dental Medicine, 100 East Newton Street, Room B08A, Boston, MA 02118, United States. skjanket@bu.edu |
| Key Words |
Genetics; Carcinogenesis; Inflammation; Epigenetics; Immunity; Infections |
| Core Tip |
A recent debate among renowned scholars prompted us to review cancer pathogenesis in a holistic approach. One group attributed cancer to “random errors in DNA multiplication” (Tomasetti C, Science, 2015) while other experts credited environmental factors for cancer causation (Wu S, Nature, 2016). However, we put forward the concept that cancer is multifactorial and both intrinsic (DNA multiplication errors) and extrinsic (environmental) factors contribute to carcinogenesis. In this review, we examined these risk factors in some detail covering genetics, epigenetics, immunity, inflammation and infections. We acknowledge the contribution of each risk factor is different in various types of cancer. In some cancers, genetics plays a powerful role while in others, metabolism contributes a stronger impact. Therefore, a holistic understanding of carcinogenesis is truly necessary considering multisystem involvement in cancer development. |
| Publish Date |
2017-07-27 01:36 |
| Citation |
Janket SJ, Qureshi M, Bascones-Martinez A, González-Febles J, Meurman JH. Holistic paradigm in carcinogenesis: Genetics, epigenetics, immunity, inflammation and oral infections. World J Immunol 2017; 7(2): 11-23 |
| URL |
http://www.wjgnet.com/2219-2824/full/v7/i2/11.htm |
| DOI |
http://dx.doi.org/10.5411/wji.v7.i2.11 |
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