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8/24/2017 4:57:59 AM | Browse: 316 | Download: 473
Publication Name World Journal of Cardiology
Manuscript ID 32517
Country/Territory United States
Received
2017-01-12 08:56
Peer-Review Started
2017-01-16 08:39
To Make the First Decision
2017-04-17 09:24
Return for Revision
2017-04-17 15:27
Revised
2017-06-22 15:27
Second Decision
2017-07-18 09:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-24 05:07
Articles in Press
2017-07-24 05:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-18 07:57
Publish the Manuscript Online
2017-08-24 04:57
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac and Cardiovascular Systems
Manuscript Type Basic Study
Article Title Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner
Manuscript Source Invited Manuscript
All Author List Danielle R Bruns, Alexander R Ghincea, Christian V Ghincea, Yasu-Taka Azuma, Peter A Watson, Michael V Autieri and Lori A Walker
Funding Agency and Grant Number
Funding Agency Grant Number
University of Colorado-Denver Center for Women’s Health Research To Walker LA
NIH NHLBI HL007822-19 (to Bruns DR)
NIH NHLBI HL117724 (to Autieri MV)
NIH NHLBI HL115575 (to Autieri MV)
Corresponding author Lori A Walker, PhD, Division of Cardiology, Department of Medicine, University of Colorado-Denver, 12700 E. 19th Ave, Aurora, CO80045, United States. lori.walker@ucdenver.edu
Keywords Cardiac dysfunction; Sex differences; Heart failure; Interleukin-19
Core Tip Heart failure (HF) is a sexually dimorphic disease. In a female-dominant model of HF, the do-minant negative cyclic AMP response-element binding protein (dnCREB) mouse, female mice show accelerated cardiac morbidity and mortality alongside downregulated interleukin-19 (IL-19) expression, while male mice maintain IL-19 expression and are protected against cardiac dysfunction. We generated a novel double transgenic mouse with dnCREB and IL-19 knockout to test the hypothesis that IL-19 is cardioprotective. We show accelerated cardiac morbidity only in male mice, supporting the hypothesis that IL-19 is a sex-specific cardioprotective cytokine.
Publish Date 2017-08-24 04:57
Citation Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J Cardiol 2017; 9(8): 673-684
Url http://www.wjgnet.com/1949-8462/full/v9/i8/673.htm
DOI http://dx.doi.org/10.4330/wjc.v9.i8.673
Full Article (PDF) WJC-9-673.pdf
Full Article (Word) WJC-9-673.doc
Manuscript File 32517-Review.docx
Answering Reviewers 32517-Answering reviewers.pdf
Audio Core Tip 32517-Audio core tip.mp3
Biostatistics Review Certificate 32517-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 32517-Conflict-of-interest statement.pdf
Copyright License Agreement 32517-Copyright assignment.pdf
Data Sharing Statement 32517-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32517-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 32517-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 32517-Institutional review board statement.pdf
Peer-review Report 32517-Peer-review(s).pdf
Scientific Misconduct Check 32517-Scientific misconduct check.pdf
Scientific Editor Work List 32517-Scientific editor work list.pdf