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Publication Name World Journal of Gastroenterology
Manuscript ID 32549
Country of Manuscript Source South Korea
2017-01-14 09:22
Peer-Review Started
2017-01-14 14:42
To Make the First Decision
2017-03-16 13:20
Return for Revision
2017-03-20 16:44
2017-03-28 16:16
Second Decision
2017-05-04 16:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-09 17:08
Articles in Press
2017-05-09 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-09 06:45
Publish the Manuscript Online
2017-06-20 12:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2
Manuscript Source Invited Manuscript
All Author List Ji-Eun Kim, So-Young Lee, Hong Kim, Ki-Jeong Kim, Won-Hyeok Choe and Bum-Joon Kim
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology NRF-2015R1C1A1A02037267
Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, South Korea HI14C0955
Correspondence To Bum-Joon Kim, Professor, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
Keywords Hepatitis B virus; Polymerase; Reverse transcriptase; Potential nucleos(t)ide analog resistance; Chronic hepatitis; Hepatocellular carcinoma
Core Tip To date, naturally occurring mutations in hepatitis B virus (HBV) reverse transcriptase region (RT) in genotype C2-infected patients have rarely been introduced in terms of clinical severity. So, this study characterized the AA substitutions at the aforementioned 42 potential NAr mutation positions in HBV RT sequences from a cohort of 131 Korean treatment-naïve CHB patients with genotype C2 infections. Notably, AA substitutions at positions involved in primary (rt184 and rt204) or secondary drug resistance (rt80 and rt180) were detected in 10 patients [1 CH patient and 9 hepatocellular carcinoma (HCC) patients] and 7 patients (1 CH and 6 HCC patients), respectively. The overall mutation frequencies in the HCC patients (3.17%, 96/3024 mutations) were significantly higher than the frequencies in the CH patients (2.09%, 52/2478 mutations), suggesting that naturally occurring NAr mutations in South Korea might contribute to liver disease progression (particularly HCC generation) in chronic patients with genotype C2 infections. In addition, a total of 3 NAr positions, rt80, rt139 and rt204 were found to be significantly related to HCC from treatment naïve Korean patients.
Publish Date 2017-06-20 12:12
Citation Kim JE, Lee SY, Kim H, Kim KJ, Choe WH, Kim BJ. Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2. World J Gastroenterol 2017; 23(23): 4222-4232
Url http://www.wjgnet.com/1007-9327/full/v23/i23/4222.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i23.4222
Full Article (PDF) WJG-23-4222.pdf
Full Article (Word) WJG-23-4222.doc
Revised Manuscript 32549-Review.docx
Peer-review Report 32549-Peer-review(s).pdf
Answering Reviewers 32549-Answering reviewers.pdf
Scientific Misconduct Check 32549-Scientific misconduct check.pdf
Scientific Editor Work List 32549-Scientific editor work list.pdf
Audio Core Tip 32549-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32549-Conflict-of-interest statement.pdf
Copyright License Agreement 32549-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32549-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 32549-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32549-Language certificate.pdf
Scientific Research Process 32549-Scientific research process.pdf