ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA
|
Manuscript Source |
Invited Manuscript |
All Author List |
Alexander Link, Cosima Langner, Wiebke Schirrmeister, Wiebke Habendorf, Jochen Weigt, Marino Venerito, Ina Tammer, Dirk Schlüter, Philipp Schlaermann, Thomas F Meyer, Thomas Wex and Peter Malfertheiner |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
the frame of ERA-NET PathoGenoMics |
BMBF-0315905D |
|
Corresponding Author |
Alexander Link, MD, PhD, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. alexander.link@med.ovgu.de |
Key Words |
Helicobacter pylori; Seropositivity; Virulence factors; CagA; VacA; Immune response |
Core Tip |
Helicobacter pylori (H. pylori) related diseases are commonly associated with cagA+ strains, although seropositivity against CagA varies among different studies. In this prospective study, we evaluated potential factors related to the H. pylori CagA-immune response. We show that anti-CagA-IgG seropositivity was strongly associated with histopathological and inflammatory factors. Most importantly, we identified H. pylori vacA polymorphism as one of the main determinants of immune response to CagA and inflammatory potential of H. pylori strains ex vivo and in vitro. Our data support the crucial role of bacterial factors that co-determine the complex interaction with H. pylori and define the immune and clinical phenotypes of the infection. |
Publish Date |
2017-07-12 06:45 |
Citation |
Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P. Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA. World J Gastroenterol 2017; 23(26): 4712-4723 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i26/4712.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i26.4712 |