Publication Name	World Journal of Orthopedics
Manuscript ID	32807
Country	Russia

Received	2017-01-25 23:54
Peer-Review Started	2017-02-02 22:58
To Make the First Decision	2017-05-23 00:50
Return for Revision	2017-05-23 08:26
Revised	2017-05-26 04:49
Second Decision	2017-07-06 09:06
Accepted by Journal Editor-in-Chief	2017-07-07 23:40
Accepted by Company Editor-in-Chief	2017-07-17 08:14
Articles in Press	2017-07-17 08:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-08 02:53
Publish the Manuscript Online	2017-09-13 00:23

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Electron probe microanalysis оf experimentally stimulated osteoarthrosis in dogs
Manuscript Source	Invited Manuscript
All Author List	Tatyana Stupina, Michael Shchudlo and Michael Stepanov
Funding Agency and Grant Number
Corresponding Author	Tatyana Stupina, Laboratory of Morphology, FSBI Russian Ilizarov Scientific Center “Restorative Traumatology and Orthopaedics”, M. Ulianova street 6, Kurgan 640014, Russia. stupinasta@mail.ru
Key Words	Osteoarthrosis; Articular cartilage; Dog; X-ray electron probe microanalysis
Core Tip	In this basic study we present the development of methods of articular cartilage preparation for X-ray-electron probe microanalysis and elements content in articular cartilage in animal experimentally induced (IOA) osteoarthrosis and during spontaneous animal aging (SA). SA was characterized by calcium and phosphorus storage in deep and calcified articular cartilage zones and compensatory increase of sulfated glycosaminoglycans in intermediate and deep zones. In IOA more intensive storage of calcium but few phosphorus in intermediate zone were marked. As for Sulphur content, all zones of uncalcified cartilage in two-year-old animals with IOA were comparable with cartilage of five-year-old intact animals.
Publish Date	2017-09-13 00:23
Citation	Stupina T, Shchudlo M, Stepanov M. Electron probe microanalysis оf experimentally stimulated osteoarthrosis in dogs. World J Orthop 2017; 8(9): 681-687
URL	http://www.wjgnet.com/2218-5836/full/v8/i9/681.htm
DOI	http://dx.doi.org/10.5312/wjo.v8.i9.681

Full Article (PDF)	WJO-8-681.pdf
Full Article (Word)	WJO-8-681.doc
Manuscript File	32807-Review.doc
Answering Reviewers	32807-Answering reviewers.pdf
Audio Core Tip	32807-Audio core tip.mp3
Biostatistics Review Certificate	32807-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32807-Conflict-of-interest statement.pdf
Copyright License Agreement	32807-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	32807-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	32807-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	32807-Language certificate.pdf
Peer-review Report	32807-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	32807-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	32807-Scientific misconduct check.pdf
Scientific Editor Work List	32807-Scientific editor work list.pdf