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7/20/2017 10:12:50 AM | Browse: 491 | Download: 354
Publication Name World Journal of Gastroenterology
Manuscript ID 32903
Country/Territory China
2017-01-30 14:51
Peer-Review Started
2017-02-01 21:34
To Make the First Decision
2017-03-16 13:20
Return for Revision
2017-03-20 16:49
2017-04-01 10:54
Second Decision
2017-05-27 01:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-01 06:29
Articles in Press
2017-06-01 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-06-20 02:56
Typeset the Manuscript
2017-07-11 11:06
Publish the Manuscript Online
2017-07-20 10:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Basic Study
Article Title Human liver chimeric mouse model based on diphtheria toxin-induced liver injury
Manuscript Source Invited Manuscript
All Author List Xiao-Nan Ren, Rong-Rong Ren, Hua Yang, Bo-Yin Qin, Xiu-Hua Peng, Li-Xiang Chen, Shun Li, Meng-Jiao Yuan, Chao Wang and Xiao-Hui Zhou
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Science and Technology Development Foundation Project 12140900300
Shanghai Municipal Commission of Health and Family Planning Project 20144Y0073
Shanghai Public Health Clinical Center Project 2014M08
National Science and Technology Major Project 2017ZX10304402-001-012
Corresponding author Xiao-Hui Zhou, MD, PhD, Professor, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jin Shan District, Shanghai 201508, China. zhouxiaohui@shaphc.org
Keywords Liver disease; Liver injury; Diphtheria toxin; Liver chimeric mouse model
Core Tip We established a novel liver chimeric mouse model following liver damage caused by intraperitoneal injection of diphtheria toxin (DT), and transplanted human hepatocytes to obtain liver-humanized mice. After 28 d, human albumin was detected in these mice. Human hepatocytes were successfully repopulated in the livers of triple-crossed albumin-cre transgenic mice, inducible DT receptor transgenic mice and severe combined immune deficient-beige mice [i.e., Alb-cre/DTR/SCID-beige (ADSB) mice]. Our inducible mouse model of humanized liver in ADSB mice may have functional applications, such as studies on hepato­cyte transplantation, hepatic regeneration and drug metabolism.
Publish Date 2017-07-20 10:12
Citation Ren XN, Ren RR, Yang H, Qin BY, Peng XH, Chen LX, Li S, Yuan MJ, Wang C, Zhou XH. Human liver chimeric mouse model based on diphtheria toxin-induced liver injury. World J Gastroenterol 2017; 23(27): 4935-4941
Url http://www.wjgnet.com/1007-9327/full/v23/i27/4935.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i27.4935
Full Article (PDF) WJG-23-4935.pdf
Full Article (Word) WJG-23-4935.doc
Manuscript File 32903-Review.docx
Answering Reviewers 32903-Answering reviewers.pdf
Audio Core Tip 32903-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32903-Conflict-of-interest statement.pdf
Copyright License Agreement 32903-Copyright assignment.doc
Data Sharing Statement 32903-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32903-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 32903-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 32903-Language certificate.doc
Scientific Research Process 32903-Scientific Research Process.pdf
Peer-review Report 32903-Peer-review(s).pdf
Scientific Misconduct Check 32903-Scientific misconduct check.pdf
Scientific Editor Work List 32903-Scientific editor work list.pdf