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Articles Published Processes
7/20/2017 10:12:50 AM | Browse: 1086 | Download: 1436
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Received |
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2017-01-30 14:51 |
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Peer-Review Started |
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2017-02-01 21:34 |
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To Make the First Decision |
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2017-03-16 13:20 |
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Return for Revision |
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2017-03-20 16:49 |
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Revised |
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2017-04-01 10:54 |
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Second Decision |
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2017-05-27 01:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-01 06:29 |
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Articles in Press |
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2017-06-01 06:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-06-20 02:56 |
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Typeset the Manuscript |
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2017-07-11 11:06 |
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Publish the Manuscript Online |
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2017-07-20 10:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Human liver chimeric mouse model based on diphtheria toxin-induced liver injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Nan Ren, Rong-Rong Ren, Hua Yang, Bo-Yin Qin, Xiu-Hua Peng, Li-Xiang Chen, Shun Li, Meng-Jiao Yuan, Chao Wang and Xiao-Hui Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Science and Technology Development Foundation Project |
12140900300 |
| Shanghai Municipal Commission of Health and Family Planning Project |
20144Y0073 |
| Shanghai Public Health Clinical Center Project |
2014M08 |
| National Science and Technology Major Project |
2017ZX10304402-001-012 |
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| Corresponding Author |
Xiao-Hui Zhou, MD, PhD, Professor, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jin Shan District, Shanghai 201508, China. zhouxiaohui@shaphc.org |
| Key Words |
Liver disease; Liver injury; Diphtheria toxin; Liver chimeric mouse model |
| Core Tip |
We established a novel liver chimeric mouse model following liver damage caused by intraperitoneal injection of diphtheria toxin (DT), and transplanted human hepatocytes to obtain liver-humanized mice. After 28 d, human albumin was detected in these mice. Human hepatocytes were successfully repopulated in the livers of triple-crossed albumin-cre transgenic mice, inducible DT receptor transgenic mice and severe combined immune deficient-beige mice [i.e., Alb-cre/DTR/SCID-beige (ADSB) mice]. Our inducible mouse model of humanized liver in ADSB mice may have functional applications, such as studies on hepatocyte transplantation, hepatic regeneration and drug metabolism. |
| Publish Date |
2017-07-20 10:12 |
| Citation |
Ren XN, Ren RR, Yang H, Qin BY, Peng XH, Chen LX, Li S, Yuan MJ, Wang C, Zhou XH. Human liver chimeric mouse model based on diphtheria toxin-induced liver injury. World J Gastroenterol 2017; 23(27): 4935-4941 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i27/4935.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i27.4935 |
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