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4/14/2017 6:51:01 PM | Browse: 327 | Download: 250
Publication Name World Journal of Gastroenterology
Manuscript ID 32914
Country/Territory Austria
Received
2017-01-30 16:30
Peer-Review Started
2017-02-01 07:52
To Make the First Decision
2017-02-10 08:49
Return for Revision
2017-02-13 12:58
Revised
2017-02-27 19:39
Second Decision
2017-03-17 18:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-03-21 11:19
Articles in Press
2017-03-21 11:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-03-31 14:14
Publish the Manuscript Online
2017-04-14 18:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Prospective Study
Article Title Biliary tract cancer stem cells - translational options and challenges
Manuscript Source Invited Manuscript
All Author List Christian Mayr, Matthias Ocker, Markus Ritter, Martin Pichler, Daniel Neureiter and Tobias Kiesslich
Funding Agency and Grant Number
Funding Agency Grant Number
tudies of the authors Mayr C, Pichler M, Neureiter D and Kiesslich T in the research field of this review were supported by research grants of the Jubiläumsfonds der Österreichischen Nationalbank 12677
tudies of the authors Mayr C, Pichler M, Neureiter D and Kiesslich T in the research field of this review were supported by research grants of the Jubiläumsfonds der Österreichischen Nationalbank 14842
the research fund of the Paracelsus Medical University Salzburg 08/07/037
the research fund of the Paracelsus Medical University Salzburg A-12/02/006-KIE
the research fund of the Paracelsus Medical University Salzburg R-16/03/083-MAY
Corresponding author Matthias Ocker, Professor, Tanslational Medicine Oncology, Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany. matthias.ocker@bayer.com
Keywords Biliary tract cancer; Cancer stem cells; Cancer stem cell markers; Tumor microenvironment; Micro-RNAs
Core Tip Using a xenograft model, researchers suc­cessfully demonstrated that as few as ten of a specific subpopulation of biliary tract cancer cells had the potency to (serially) establish and recapitulate biliary tract cancer in immunodeficient mice. Furthermore, expression of established cancer stem cell markers, cancer stem cell-related signaling pathways and micro-RNAs was reported in biliary specimens and cell lines - in most cases associated with clinical outcome. Based on these results, the existence of cancer stem cells in biliary tract is well-founded and potentially harbors new options for development of therapeutic strategies.
Publish Date 2017-04-14 18:51
Citation Mayr C, Ocker M, Ritter M, Pichler M, Neureiter D, Kiesslich T. Biliary tract cancer stem cells - translational options and challenges. World J Gastroenterol 2017; 23(14): 2470-2482
Url http://www.wjgnet.com/1007-9327/full/ v23/i14/2470.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i14.2470
Full Article (PDF) WJG-23-2470.pdf
Full Article (Word) WJG-23-2470.doc
Manuscript File 32914-Review.docx
Answering Reviewers 32914-Answering reviewers.pdf
Audio Core Tip 32914-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32914-Conflict-of-interest statement.pdf
Copyright License Agreement 32914-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32914-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 32914-Language certificate.pdf
Peer-review Report 32914-Peer-review(s).pdf
Scientific Misconduct Check 32914-Scientific misconduct check.pdf
Scientific Editor Work List 32914-Scientific editor work list.pdf