Publication Name	World Journal of Gastroenterology
Manuscript ID	32914
Country	Austria

Received	2017-01-30 16:30
Peer-Review Started	2017-02-01 07:52
To Make the First Decision	2017-02-10 08:49
Return for Revision	2017-02-13 12:58
Revised	2017-02-27 19:39
Second Decision	2017-03-17 18:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-21 11:19
Articles in Press	2017-03-21 11:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-31 14:14
Publish the Manuscript Online	2017-04-14 18:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Biliary tract cancer stem cells - translational options and challenges
Manuscript Source	Invited Manuscript
All Author List	Christian Mayr, Matthias Ocker, Markus Ritter, Martin Pichler, Daniel Neureiter and Tobias Kiesslich
Funding Agency and Grant Number	Funding Agency Grant Number tudies of the authors Mayr C, Pichler M, Neureiter D and Kiesslich T in the research field of this review were supported by research grants of the Jubiläumsfonds der Österreichischen Nationalbank 12677 tudies of the authors Mayr C, Pichler M, Neureiter D and Kiesslich T in the research field of this review were supported by research grants of the Jubiläumsfonds der Österreichischen Nationalbank 14842 the research fund of the Paracelsus Medical University Salzburg 08/07/037 the research fund of the Paracelsus Medical University Salzburg A-12/02/006-KIE the research fund of the Paracelsus Medical University Salzburg R-16/03/083-MAY
Corresponding Author	Matthias Ocker, Professor, Tanslational Medicine Oncology, Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany. matthias.ocker@bayer.com
Key Words	Biliary tract cancer; Cancer stem cells; Cancer stem cell markers; Tumor microenvironment; Micro-RNAs
Core Tip	Using a xenograft model, researchers suc­cessfully demonstrated that as few as ten of a specific subpopulation of biliary tract cancer cells had the potency to (serially) establish and recapitulate biliary tract cancer in immunodeficient mice. Furthermore, expression of established cancer stem cell markers, cancer stem cell-related signaling pathways and micro-RNAs was reported in biliary specimens and cell lines - in most cases associated with clinical outcome. Based on these results, the existence of cancer stem cells in biliary tract is well-founded and potentially harbors new options for development of therapeutic strategies.
Publish Date	2017-04-14 18:51
Citation	Mayr C, Ocker M, Ritter M, Pichler M, Neureiter D, Kiesslich T. Biliary tract cancer stem cells - translational options and challenges. World J Gastroenterol 2017; 23(14): 2470-2482
URL	http://www.wjgnet.com/1007-9327/full/ v23/i14/2470.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i14.2470

Full Article (PDF)	WJG-23-2470.pdf
Full Article (Word)	WJG-23-2470.doc
Manuscript File	32914-Review.docx
Answering Reviewers	32914-Answering reviewers.pdf
Audio Core Tip	32914-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32914-Conflict-of-interest statement.pdf
Copyright License Agreement	32914-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	32914-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	32914-Language certificate.pdf
Peer-review Report	32914-Peer-review(s).pdf
Scientific Misconduct Check	32914-Scientific misconduct check.pdf
Scientific Editor Work List	32914-Scientific editor work list.pdf