Publication Name	World Journal of Gastroenterology
Manuscript ID	33058
Country	Italy

Received	2017-02-04 15:36
Peer-Review Started	2017-02-06 21:26
To Make the First Decision	2017-03-16 13:18
Return for Revision	2017-03-22 09:25
Revised	2017-04-03 12:02
Second Decision	2017-05-04 17:44
Accepted by Journal Editor-in-Chief	2017-05-05 07:19
Accepted by Executive Editor-in-Chief	2017-05-09 17:11
Articles in Press	2017-05-09 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-08 03:22
Publish the Manuscript Online	2017-06-20 12:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Editorial
Article Title	Attenuated adenomatous polyposis of the large bowel: Present and future
Manuscript Source	Invited Manuscript
All Author List	Luca Roncucci, Monica Pedroni and Francesco Mariani
Funding Agency and Grant Number
Corresponding Author	Luca Roncucci, MD, PhD, Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Via Del Pozzo 71, I-41125 Modena, Italy. luca.roncucci@unimore.it
Key Words	Attenuated adenomatous polyposis; Genetic testing; Surveillance; Attenuated familial adenomatous polyposis; Adenomatous polyposis coli; MUTYH
Core Tip	Attenuated adenomatous polyposis is a poorly understood syndrome, which may be defined as the presence of 10-99 synchronous adenomas in the large bowel, when at least 50% of the polyps removed are adenomatous. It is a variant of Familial Adenomatous Polyposis with a milder phenotype. In less than 50% of cases, it is caused by adenomatous polyposis coli (APC) or MUTYH mutations, and less frequently by other genes. Surveillance should rely on colonoscopy at regular intervals, with removal of adenomas and careful histological examination. If removal of all polyps is not possible or advanced lesions are observed, the surgical treatment is mandatory.
Publish Date	2017-06-20 12:12
Citation	Roncucci L, Pedroni M, Mariani F. Attenuated adenomatous polyposis of the large bowel: Present and future. World J Gastroenterol 2017; 23(23): 4135-4139
URL	http://www.wjgnet.com/1007-9327/full/v23/i23/4135.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i23.4135

Full Article (PDF)	WJG-23-4135.pdf
Full Article (Word)	WJG-23-4135.doc
Manuscript File	33058-Review.docx
Answering Reviewers	33058-Answering reviewers.pdf
Audio Core Tip	33058-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33058-Conflict-of-interest statement.pdf
Copyright License Agreement	33058-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	33058-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	33058-Language certificate.pdf
Peer-review Report	33058-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33058-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33058-Scientific misconduct check.pdf
Scientific Editor Work List	33058-Scientific editor work list.pdf