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6/26/2017 10:23:06 AM | Browse: 77 | Download: 66
Publication Name World Journal of Gastroenterology
Manuscript ID 33214
Country of Manuscript Source Italy
Received
2017-02-07 18:53
Peer-Review Started
2017-02-10 09:03
To Make the First Decision
2017-03-16 11:51
Return for Revision
2017-03-21 11:37
Revised
2017-04-13 23:50
Second Decision
2017-05-15 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-05-19 08:19
Articles in Press
2017-05-19 08:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-06-16 01:08
Publish the Manuscript Online
2017-06-26 10:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Review
Article Title Implication of the Hedgehog pathway in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Carminia Maria Della Corte, Giuseppe Viscardi, Federica Papaccio, Giovanna Esposito, Giulia Martini, Davide Ciardiello, Erika Martinelli, Fortunato Ciardiello and Floriana Morgillo
Funding Agency and Grant Number
Correspondence To Floriana Morgillo, MD, PhD, Assistant Professor, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale “F. Magrassi e A. Lanzara”, Università degli studi della Campania “Luigi Vanvitelli”, Via S. Pansini 5, 80131 Naples, Italy. florianamorgillo@yahoo.com
Keywords Hedgehog; epithelial-mesenchymal transition; hepatocellular carcinoma; hepatocarcinogenesis; prognosis
Core Tip The hedgehog (HH) pathway is involved in the embryonic development of liver, and its reactivation plays a substantial role in sustaining cancer cell growth and progression in hepatocellular carcinoma (HCC). In hepatocarcinogenesis, HH signalling is required for differentiation, proliferation and polarity of liver embryonic cells. High levels of expression of HH com­ponents in HCC tissues correlate with mesenchymal properties and maintain the proliferation of cancer stem cells, which is a dynamic source of malignant cells in HCC progression. Current data on HH inhibition in preclinical models further confirm the role of HH and deserve future investigations in a clinical setting.
Publish Date 2017-06-26 10:23
Citation Della Corte cm, Viscardi G, Papaccio F, Esposito G, Martini G, Ciardiello D, Martinelli E, Ciardiello F, Morgillo F. Implication of the Hedgehog pathway in hepatocellular carcinoma. World J Gastroenterol 2017; 23(24): 4330-4340
Url http://www.wjgnet.com/1007-9327/full/v23/i24/4330.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i24.4330
Full Article (PDF) WJG-23-4330.pdf
Full Article (Word) WJG-23-4330.doc
Revised Manuscript 33214-Review.docx
Peer-review Report 33214-Peer-review(s).pdf
Answering Reviewers 33214-Answering reviewers.pdf
Scientific Misconduct Check 33214-Scientific misconduct check.pdf
Scientific Editor Work List 33214-Scientific editor work list.pdf
Audio 33214-Audio core tip.mp3
Conflict-of-Interest Statement 33214-Conflict-of-interest statement.pdf
Copyright Assignment 33214-Copyright assignment.pdf
Non-Native Speakers of English 33214-Language certificate.pdf