Publication Name	World Journal of Gastroenterology
Manuscript ID	3331
Country	Greece

Received	2013-04-23 09:50
Peer-Review Started	2013-04-23 19:47
First Decision by Editorial Office Director
Return for Revision	2013-05-17 20:07
Revised	2013-06-06 15:06
Publication Fee Transferred
Second Decision by Editor	2013-07-17 18:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-07-18 13:26
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-18 20:34
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Pleomorphic hepatocellular carcinoma following consumption of hypericum perforatum in alcoholic cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Evangeli S Lampri, Elli Ioachim, Haralampos Harissis, Eufemia Balasi, Antigoni Mitselou and Vasiliki Malamou-Mitsi
Funding Agency and Grant Number
Corresponding Author	Evangeli S Lampri, MD, Department of Pathology, Ioannina University Medical School, Leoforos Stavrou Niarxou, PO Box 1186, 45110 Ioannina, Greece. evangeli.lampri@gmail.com
Key Words	Hepatocellular carcinoma; Giant cell carcinoma; Hypericum perforatum; St John’s wort; Syncytial giant cell; Pleomorphic liver tumor; Alcoholic cirrhosis
Core Tip	This case report describes the clinicopathological-based finding of an unusual hepatocellular carcinoma (HCC) with syncytial giant cells (SGCs) in a 55-year-old man with a 6-year history of alcoholic cirrhosis. Unlike the previous case reports of these rare tumor types that have demonstrated the mesenchymal and non-neoplastic nature of the giant cells, the current case showed an epithelial and hepatocyte-originated neoplasmic nature. An intriguing feature of case is the patient’s 6-month history of hypericum perforatum/St John’s wort self-medication, which may have prompted the cirrhosis or HCC progression or the unusual SGC manifestation.
Publish Date	2014-02-26 11:18
Citation	Lampri ES, Ioachim E, Harisis H, Balasi E, Mitselou A, Malamou-Mitsi V. Pleomorphic hepatocellular carcinoma following consumption of hypericum perforatum in alcoholic cirrhosis. World J Gastroenterol 2014; 20(8): 2113-2116
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/2113.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.2113

Full Article (PDF)	WJG-20-2113.pdf
Full Article (Word)	WJG-20-2113.doc
Manuscript File	3331-Review.docx
Answering Reviewers	3331-Answering reviewers.pdf
Copyright License Agreement	3331-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	3331-Language certificate.pdf
Peer-review Report	3331-Peer review(s).pdf
Scientific Editor Work List	3331-Scientific editor work list.doc