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Articles Published Processes
9/7/2017 8:51:55 AM | Browse: 1052 | Download: 1661
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Received |
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2017-02-07 10:17 |
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Peer-Review Started |
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2017-02-08 18:31 |
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To Make the First Decision |
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2017-05-12 09:24 |
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Return for Revision |
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2017-05-16 09:00 |
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Revised |
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2017-05-31 14:57 |
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Second Decision |
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2017-07-05 23:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-12 06:12 |
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Articles in Press |
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2017-07-12 06:12 |
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Publication Fee Transferred |
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2017-07-26 03:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-08-03 19:18 |
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Publish the Manuscript Online |
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2017-09-07 08:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Behavioral Sciences |
| Manuscript Type |
Basic Study |
| Article Title |
Pharmacological evaluation of NSAID-induced gastropathy as a “Translatable” model of referred visceral sensitivity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michele Hummel, Terri Knappenberger, Meghan Reilly and Garth Whiteside |
| Funding Agency and Grant Number |
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| Corresponding Author |
Michele Hummel, PhD, Trevena, Inc., 1018 West 8th Avenue, Suite A, , King of Prussia, PA 19406, United States. mhummel@trevena.com |
| Key Words |
Visceral hypersensitivity; Pain; Translation; Guanylate cyclase C; Non-steroidal anti-inflammatory drugs; Transient receptor potential channel |
| Core Tip |
Recently, standard animal models of pain have been vehemently challenged for their inability to successfully predict human clinical outcomes. Further, few animal models have been represented with reasonable translational value for conditions presenting with visceral pain. Non-steroidal anti-inflammatory drug -induced gastropathy represents a translatable model of visceral hypersensitivity in which several pain targets have demonstrated reliable sensitivity when assayed. Further, this model is robust enough that proper pharmacological evaluation can be conducted. Overall, this model has the potential to efficiently triage molecules with pain-attenuating properties for their utility in gastrointestinal disorders that include pain as a hallmark symptom. |
| Publish Date |
2017-09-07 08:51 |
| Citation |
Hummel M, Knappenberger T, Reilly M, Whiteside GT. Pharmacological evaluation of NSAID-induced gastropathy as a “Translatable” model of referred visceral sensitivity. World J Gastroenterol 2017; 23(33): 6065-6076 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i33/6065.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i33.6065 |
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