Publication Name	World Journal of Gastroenterology
Manuscript ID	33358
Country	Italy

Received	2017-02-06 10:00
Peer-Review Started	2017-02-08 10:03
To Make the First Decision	2017-02-23 09:30
Return for Revision	2017-03-06 18:06
Revised	2017-04-11 23:00
Second Decision	2017-07-21 07:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-07-24 08:00
Articles in Press	2017-07-24 08:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-10 13:07
Publish the Manuscript Online	2017-08-14 04:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Wilson’s disease: Prospective developments towards new therapies
Manuscript Source	Invited Manuscript
All Author List	Giusy Ranucci, Roman Polishchuck and Raffaele Iorio
Funding Agency and Grant Number
Corresponding Author	Raffaele Iorio, MD, Associate Professor, Department of Translational Medical Science, Section of Pediatrics, University Federico II, Via Pansini 5, Naples 80131, Italy. riorio@unina.it
Key Words	ATP7B; Stem cell-derived hepatocyte like cells; Methanobactin; Heat shock protein 70; p38; JNK; Correctors; Translational medicine; Precision medicine
Core Tip	Hepatocytes derived from human-induced pluripotent stem cells hold great promise for the drug discovery process, especially for Wilson’s disease (WD). Therapeutic approaches offering correction of the ATP7B mutant function and/or less toxic suppression of copper accumulation are promising and could be available shortly. In particular, protein quality control components and their regulatory networks represent attractive new targets for WD-causing mutant correc­tion. Cell and gene therapies, however, will require more studies before they can be considered for clinical trials. A key goal for WD advancement is international cooperation of specialized centers to overcome limited availability of patients for study.
Publish Date	2017-08-14 04:00
Citation	Ranucci G, Polishchuck R, Iorio R. Wilson’s disease: Prospective developments towards new therapies. World J Gastroenterol 2017; 23(30): 5451-5456
URL	http://www.wjgnet.com/1007-9327/full/v23/i30/5451.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i30.5451

Full Article (PDF)	WJG-23-5451.pdf
Full Article (Word)	WJG-23-5451.doc
Manuscript File	33358-Review.docx
Answering Reviewers	33358-Answering reviewers.pdf
Audio Core Tip	33358-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33358-Conflict-of-interest statement.pdf
Copyright License Agreement	33358-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20170203213405.pdf
Non-Native Speakers of English Editing Certificate	33358-Language certificate.pdf
Supplementary Material	33358_5 33358-Conflict-of-interest statement ranucci.jpg
Peer-review Report	33358-Peer-review(s).pdf
Scientific Misconduct Check	33358-Scientific misconduct check.pdf
Scientific Editor Work List	33358-Scientific editor work list.pdf