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Articles Published Processes
7/28/2017 8:16:18 AM | Browse: 1109 | Download: 2166
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Received |
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2017-02-06 08:31 |
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Peer-Review Started |
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2017-02-08 13:38 |
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To Make the First Decision |
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2017-03-16 11:51 |
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Return for Revision |
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2017-03-21 11:35 |
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Revised |
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2017-03-31 23:24 |
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Second Decision |
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2017-05-04 17:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-05-09 16:57 |
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Articles in Press |
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2017-05-09 16:57 |
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Publication Fee Transferred |
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2017-06-28 16:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-22 12:33 |
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Publish the Manuscript Online |
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2017-07-28 08:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Myo-inositol reduces β-catenin activation in colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Emily M Bradford, Corey A Thompson, Tatiana Goretsky, Guang-Yu Yang, Luz M Rodriguez, Linheng Li and Terrence A Barrett |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Veterans Affairs Merit Award |
IO1CX001353 (to Barrett TA) |
| National Institutes of Health |
2R01DK095662-06A1 (to Barrett TA) |
| National Cancer Institute at the National Institutes of Health |
N01-CN-35157 (to Bergan R) |
| Training Program in Oncogenesis and Developmental Biology through the National Cancer Institute |
NCI T32 CA080621, (to Bradford EM) |
| National Institutes of Health |
8 P20GM103527-05 |
| Institutional Development Award from the National Institute of General Medical Sciences of the National Institutes of Health |
8 P20GM103527-05 |
| American Physiological Society STEP-UP Fellowship |
(to Thompson CA) |
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| Corresponding Author |
Terrence A Barrett, Division of Gastroenterology, Department of Internal Medicine, University of Kentucky, Lexington, 800 E. Rose St. MN649, Lexington, KY 40536, United States. t.barrett@uky.edu |
| Key Words |
Chemoprevention; Dysplasia; Biomarker; Stem cell; Colitis-associated cancer |
| Core Tip |
We report that dietary myo-inositol reduced inflammation and intestinal stem cell activation in both genetic and chemically-induced mouse models of colitis. In a limited clinical trial of colitis patients with a history of recurrent low grade dysplasia (LGD), myo-inositol reduced the number of intestinal crypts with activated stem cells. This study demonstrated for the first time that nuclear pβ-cateninS552 staining discriminates between patients with inflammation and those with a history of LGD, suggesting that nuclear pβ-cateninS552 staining may reflect local expansions of activated stem cells with neoplastic potential. Based on these data, we propose a more extensive clinical trial. |
| Publish Date |
2017-07-28 08:16 |
| Citation |
Bradford EM, Thompson CA, Goretsky T, Yang GY, Rodriguez LM, Li L, Barrett TA. Myo-inositol reduces β-catenin activation in colitis. World J Gastroenterol 2017; 23(28): 5115-5126 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i28/5115.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i28.5115 |
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