Publication Name	World Journal of Gastroenterology
Manuscript ID	33523
Country	China

Received	2017-02-14 08:39
Peer-Review Started	2017-02-14 17:16
To Make the First Decision	2017-04-07 17:20
Return for Revision	2017-04-07 17:24
Revised	2017-05-14 13:48
Second Decision	2017-06-06 00:42
Accepted by Journal Editor-in-Chief	2017-06-08 00:47
Accepted by Company Editor-in-Chief	2017-06-12 08:41
Articles in Press	2017-06-12 08:41
Publication Fee Transferred	2017-06-13 05:01
Edit the Manuscript by Language Editor	2017-06-29 21:13
Typeset the Manuscript	2017-08-14 02:46
Publish the Manuscript Online	2017-08-19 11:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Protective effects of Foeniculum vulgare root bark extract against carbon tetrachloride-induced hepatic fibrosis in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Cai Zhang, Xing Tian, Ke Zhang, Guo-Yu Li, Hang-Yu Wang and Jin-Hui Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Key Technology R&D Program 2012BAI30B02
Corresponding Author	Xing Tian , PhD, School of Pharmacy, Shihezi University, North Road 4, Shihezi 832002, Xinjiang Uygur Autonomous Region, China. tianxing2017@shzu.edu.cn
Key Words	Hepatic fibrosis; Foeniculum vulgare root bark; Histopathology; Carbon tetrachloride; TGF-β1
Core Tip	Hepatic fibrosis is a wound-healing patho­logical process resulting from chronic hepatic injuries. In the present study, hepatoprotective effects of Foeniculum vulgare root bark (FVRB), a traditional Uyghur medicine, against carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice were investigated. FVRB reduced serum levels of aspartate aminotransferase, alanine aminotransferase, triglyceride, hexadecenoic acid and laminin. Furthermore, FVRB inhibited CCl4-induced TGF-β1, MMP-9, TIMP-1 expression and histopathological changes. Our study indicated that the protective effects of FVRB are through inhibiting lipid peroxidation and collagen formation in liver tissue of liver fibrosis mice.
Publish Date	2017-08-19 11:33
Citation	Zhang C, Tian X, Zhang K, Li GY, Wang HY, Wang JH. Protective effects of Foeniculum vulgare root bark extract against carbon tetrachloride-induced hepatic fibrosis in mice. World J Gastroenterol 2017; 23(31): 5722-5731
URL	http://www.wjgnet.com/1007-9327/full/v23/i31/5722.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i31.5722

Full Article (PDF)	WJG-23-5722.pdf
Full Article (Word)	WJG-23-5722.doc
Manuscript File	33523-Review.docx
Answering Reviewers	33523-Answering reviewers.pdf
Audio Core Tip	33523-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33523-Conflict-of-interest statement.pdf
Copyright License Agreement	33523-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	33523-Grant application form(s).pdf
Peer-review Report	33523-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	33523-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	33523-Scientific misconduct check.pdf
Scientific Editor Work List	33523-Scientific editor work list.pdf