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9/28/2017 10:01:54 AM | Browse: 962 | Download: 1290
Publication Name World Journal of Gastroenterology
Manuscript ID 33590
Country/Territory Ireland
Received
2017-02-20 10:34
Peer-Review Started
2017-02-20 21:14
To Make the First Decision
2017-04-07 17:20
Return for Revision
2017-04-07 17:26
Revised
2017-06-09 14:01
Second Decision
2017-07-05 23:51
Accepted by Journal Editor-in-Chief
2017-07-07 03:46
Accepted by Company Editor-in-Chief
2017-07-12 06:13
Articles in Press
2017-07-12 06:13
Publication Fee Transferred
2017-09-13 10:45
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-25 12:31
Publish the Manuscript Online
2017-09-28 10:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Basic Study
Article Title Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori
Manuscript Source Unsolicited Manuscript
All Author List Michael T Cairns, Ananya Gupta, Julie A Naughton, Marian Kane, Marguerite Clyne and Lokesh Joshi
Funding Agency and Grant Number
Funding Agency Grant Number
Science Foundation Ireland, SFI AGRC Grant Code 08/SRC/B1393
Corresponding Author Michael T Cairns, Senior Research Fellow, Glycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland Galway, University Rd, Galway H91 CF50, Ireland. michael.cairns@nuigalway.ie
Key Words Glycosylation; Adherent mucus; Gastric; HT29-MTX-E12; H. pylori strain 26695; Transcriptomics
Core Tip Few studies on Helicobacter pylori (H. pylori) infection focus on glycosylation-related genes in the host cells yet key cell-cell interactions are likely mediated through surface glycoconjugates. We use HT29-MTX-E12 cells, a promising and novel model of the stomach epithelium, to investigate the transcriptomic effects of H. pylori infection. HT29-MTX-E12 cells produce a thick adherent mucus layer and show a level of pluripotency that gastric cells naturally present and which some other model cell lines do not. Furthermore both H. pylori strain 26695 (lacks BabA adhesin) and HT29-MTX-E12 host cells (TLR2-negative) have some features atypical of more common models of H. pylori infection.
Publish Date 2017-09-28 10:01
Citation Cairns MT, Gupta A, Naughton JA, Kane M, Clyne M, Joshi L. Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori. World J Gastroenterol 2017; 23(37): 6817-6832
URL http://www.wjgnet.com/1007-9327/full/v23/i37/6817.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i37.6817
Full Article (PDF) WJG-23-6817.pdf
Full Article (Word) WJG-23-6817.doc
Manuscript File 33590-Review.docx
Answering Reviewers 33590-Answering reviewers.pdf
Audio Core Tip 33590-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 33590-Conflict-of-interest statement.pdf
Copyright License Agreement 33590-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33590-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 33590-Institutional review board statement.pdf
Supplementary Material 33590-Supplementary material.pdf
Peer-review Report 33590-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33590-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 33590-Scientific misconduct check.pdf
Scientific Editor Work List 33590-Scientific editor work list.pdf