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Articles Published Processes
9/28/2017 10:01:54 AM | Browse: 1107 | Download: 1690
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Received |
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2017-02-20 10:34 |
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Peer-Review Started |
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2017-02-20 21:14 |
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To Make the First Decision |
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2017-04-07 17:20 |
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Return for Revision |
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2017-04-07 17:26 |
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Revised |
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2017-06-09 14:01 |
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Second Decision |
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2017-07-05 23:51 |
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Accepted by Journal Editor-in-Chief |
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2017-07-07 03:46 |
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Accepted by Executive Editor-in-Chief |
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2017-07-12 06:13 |
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Articles in Press |
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2017-07-12 06:13 |
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Publication Fee Transferred |
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2017-09-13 10:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-25 12:31 |
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Publish the Manuscript Online |
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2017-09-28 10:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michael T Cairns, Ananya Gupta, Julie A Naughton, Marian Kane, Marguerite Clyne and Lokesh Joshi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science Foundation Ireland, SFI AGRC Grant Code |
08/SRC/B1393 |
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| Corresponding Author |
Michael T Cairns, Senior Research Fellow, Glycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland Galway, University Rd, Galway H91 CF50, Ireland. michael.cairns@nuigalway.ie |
| Key Words |
Glycosylation; Adherent mucus; Gastric; HT29-MTX-E12; H. pylori strain 26695; Transcriptomics |
| Core Tip |
Few studies on Helicobacter pylori (H. pylori) infection focus on glycosylation-related genes in the host cells yet key cell-cell interactions are likely mediated through surface glycoconjugates. We use HT29-MTX-E12 cells, a promising and novel model of the stomach epithelium, to investigate the transcriptomic effects of H. pylori infection. HT29-MTX-E12 cells produce a thick adherent mucus layer and show a level of pluripotency that gastric cells naturally present and which some other model cell lines do not. Furthermore both H. pylori strain 26695 (lacks BabA adhesin) and HT29-MTX-E12 host cells (TLR2-negative) have some features atypical of more common models of H. pylori infection. |
| Publish Date |
2017-09-28 10:01 |
| Citation |
Cairns MT, Gupta A, Naughton JA, Kane M, Clyne M, Joshi L. Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori. World J Gastroenterol 2017; 23(37): 6817-6832 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i37/6817.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i37.6817 |
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