Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	33683
Country	United States

Received	2017-02-25 11:53
Peer-Review Started	2017-02-27 08:17
To Make the First Decision	2017-05-23 00:52
Return for Revision	2017-06-12 04:03
Revised	2017-06-27 00:31
Second Decision	2017-07-28 05:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-04 06:17
Articles in Press	2017-08-04 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-31 09:07
Publish the Manuscript Online	2017-09-11 01:10

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Epigenetics of gastroenteropancreatic neuroendocrine tumors: A clinicopathologic perspective
Manuscript Source	Invited Manuscript
All Author List	Brendan M Finnerty, Katherine D Gray, Maureen D Moore, Rasa Zarnegar and Thomas J Fahey III
Funding Agency and Grant Number
Corresponding Author	Brendan M Finnerty, MD, Department of Surgery, New York Presbyterian Hospital, Weill Cornell Medicine, York Ave, Suite A1027, New York, NY 10065, United States. bmf9002@nyp.org
Key Words	Epigenetics; Carcinoid; Neuroendocrine; MicroRNA; Methylation; Histone modifications; Chromatin remodeling; LncRNA
Core Tip	Herein, we describe a review of the literature addressing known epigenetic changes which are thought to lead to the development of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Through a variety of scientific works, methylation patterns, chromatin remodeling alterations, and microRNA and long non-coding RNA differential expression profiles have been identified and in many cases correlated with GEP-NET malignancy and clinical outcomes. This overview shows the strong foundation which exists and underlines the importance of future work to evaluate the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets.
Publish Date	2017-09-11 01:10
Citation	Finnerty BM, Gray KD, Moore MD, Zarnegar R, Fahey Ⅲ TJ. Epigenetics of gastroenteropancreatic neuroendocrine tumors: A clinicopathologic perspective. World J Gastrointest Oncol 2017; 9(9): 341-353
URL	http://www.wjgnet.com/1948-5204/full/v9/i9/341.htm
DOI	http://dx.doi.org/10.4251/wjgo.v9.i9.341

Full Article (PDF)	WJGO-9-341.pdf
Full Article (Word)	WJGO-9-341.doc
Manuscript File	33683-Review.docx
Answering Reviewers	33683-Answering reviewers.pdf
Audio Core Tip	33683-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	33683-Conflict-of-interest statement.pdf
Copyright License Agreement	33683-Copyright assignment.PDF
Supplementary Material	33683-Supplementary material.pptx
Peer-review Report	33683-Peer-review(s).pdf
Scientific Misconduct Check	33683-Scientific misconduct check.pdf
Scientific Editor Work List	33683-Scientific editor work list.pdf