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9/25/2017 8:56:57 AM | Browse: 992 | Download: 1920
Publication Name World Journal of Gastroenterology
Manuscript ID 33735
Country/Territory Italy
Received
2017-02-28 09:37
Peer-Review Started
2017-02-28 16:54
To Make the First Decision
2017-04-21 10:36
Return for Revision
2017-04-28 17:11
Revised
2017-05-17 07:51
Second Decision
2017-06-27 00:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-04 06:11
Articles in Press
2017-07-04 06:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-18 04:10
Publish the Manuscript Online
2017-09-25 08:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Control Study
Article Title Genetic biomarkers for hepatocellular cancer risk in a caucasian population
Manuscript Source Invited Manuscript
All Author List Elena De Mattia, Erika Cecchin, Jerry Polesel, Alessia Bignucolo, Rossana Roncato, Francesco Lupo, Marina Crovatto, Angela Buonadonna, Claudio Tiribelli and Giuseppe Toffoli
Funding Agency and Grant Number
Funding Agency Grant Number
This work was supported by an AIRC (Italian Association for Cancer Research) regional grant 2004.
Corresponding Author Giuseppe Toffoli, MD, Clinical and Experimental Pharmacology, CRO- National Cancer Institute, Via Franco Gallini n. 2, Aviano 33081, Italy. gtoffoli@cro.it
Key Words ERCC1; XRCC3; GST-P1; CYP17A1; MDR-1; Polymorphisms; Hepatocellular carcinoma risk; Early diagnosis; Antiviral therapy; Hepatitis B viral/hepatitis C viral
Core Tip It is a great challenge to define new bio­markers of hepatocellular carcinoma (HCC) risk for HCC management. This work identified five genetic markers in key pathways linked to hepatocarcinogenesis (ERCC1 rs3212986, GSTP1 rs1138272, CYP17A1 rs743572, XRCC3 rs1799794, and ABCB1 rs112850), which could predict individual HCC susceptibility, particularly in a high-risk [hepatitis B viral/hepatitis C viral (HCV)-infected] Caucasian population. We also identified potential gene-gene interactions that should be included in the definition of HCC risk. These findings could contribute to improved HCC surveillance, early cancer diagnoses, and potential curative therapies. For patients with HCV, these markers could be considered selection criteria for the personalized use of recently developed, highly expensive anti-viral therapies.
Publish Date 2017-09-25 08:56
Citation De Mattia E, Cecchin E, Polesel J, Bignucolo A, Roncato R, Lupo F, Crovatto M, Buonadonna A, Tiribelli C, Toffoli G. Genetic biomarkers for hepatocellular cancer risk in a caucasian population. World J Gastroenterol 2017; 23(36): 6674-6684
URL http://www.wjgnet.com/1007-9327/full/v23/i36/6674.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i36.6674
Full Article (PDF) WJG-23-6674.pdf
Full Article (Word) WJG-23-6674.doc
Manuscript File 33735-Review.docx
Answering Reviewers 33735-Answering reviewers.pdf
Audio Core Tip 33735-Audio core tip.mp3
Biostatistics Review Certificate 33735-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33735-Conflict-of-interest statement.pdf
Copyright License Agreement 33735_33735-Copyright assignmentpdf.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 33735-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20170227194134.pdf
Institutional Review Board Approval Form or Document Institutional_Review_Board_Statement_20170227192902.docx
Supplementary Material Supplementary_Material_20170227194303.docx
Peer-review Report 33735-Peer-review(s).pdf
Scientific Misconduct Check 33735-Scientific misconduct check.pdf
Scientific Editor Work List 33735-Scientific editor work list.pdf