ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Case Control Study |
Article Title |
Genetic biomarkers for hepatocellular cancer risk in a caucasian population
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Manuscript Source |
Invited Manuscript |
All Author List |
Elena De Mattia, Erika Cecchin, Jerry Polesel, Alessia Bignucolo, Rossana Roncato, Francesco Lupo, Marina Crovatto, Angela Buonadonna, Claudio Tiribelli and Giuseppe Toffoli |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
This work was supported by an AIRC (Italian Association for Cancer Research) regional grant 2004. |
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Corresponding Author |
Giuseppe Toffoli, MD, Clinical and Experimental Pharmacology, CRO- National Cancer Institute, Via Franco Gallini n. 2, Aviano 33081, Italy. gtoffoli@cro.it |
Key Words |
ERCC1; XRCC3; GST-P1; CYP17A1; MDR-1; Polymorphisms; Hepatocellular carcinoma risk; Early diagnosis; Antiviral therapy; Hepatitis B viral/hepatitis C viral |
Core Tip |
It is a great challenge to define new biomarkers of hepatocellular carcinoma (HCC) risk for HCC management. This work identified five genetic markers in key pathways linked to hepatocarcinogenesis (ERCC1 rs3212986, GSTP1 rs1138272, CYP17A1 rs743572, XRCC3 rs1799794, and ABCB1 rs112850), which could predict individual HCC susceptibility, particularly in a high-risk [hepatitis B viral/hepatitis C viral (HCV)-infected] Caucasian population. We also identified potential gene-gene interactions that should be included in the definition of HCC risk. These findings could contribute to improved HCC surveillance, early cancer diagnoses, and potential curative therapies. For patients with HCV, these markers could be considered selection criteria for the personalized use of recently developed, highly expensive anti-viral therapies. |
Publish Date |
2017-09-25 08:56 |
Citation |
De Mattia E, Cecchin E, Polesel J, Bignucolo A, Roncato R, Lupo F, Crovatto M, Buonadonna A, Tiribelli C, Toffoli G. Genetic biomarkers for hepatocellular cancer risk in a caucasian population. World J Gastroenterol 2017; 23(36): 6674-6684 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i36/6674.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i36.6674 |