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Articles Published Processes
7/20/2017 10:12:50 AM | Browse: 1063 | Download: 2081
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Received |
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2017-03-01 09:39 |
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Peer-Review Started |
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2017-03-02 08:43 |
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To Make the First Decision |
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2017-03-16 11:34 |
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Return for Revision |
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2017-03-17 15:51 |
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Revised |
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2017-03-31 23:29 |
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Second Decision |
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2017-06-16 12:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-19 08:42 |
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Articles in Press |
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2017-06-19 08:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-06-24 21:13 |
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Typeset the Manuscript |
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2017-07-15 05:11 |
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Publish the Manuscript Online |
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2017-07-20 10:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ching-Pin Lin, Wen-Chen Chuang, Fung-Jou Lu and Chih-Yen Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chung Shan Medical University |
CSMU0150011 |
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| Corresponding Author |
Chih-Yen Chen, MD, PhD, Division of Gastroenterology and Hepatology, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Road Taipei 112, Taiwan. chency@vghtpe.gov.tw |
| Key Words |
hydrogen; chronic plus binge EtOH feeding; antioxidant; protective cytokine; acyl ghrelin; female mice |
| Core Tip |
hydrogen-rich water (HRW), a safe and effective antioxidant with minimal side effects, is used in preventive and clinical applications. Few studies have investigated the effects of hydrogen on early alcoholic liver disease. The present study evaluated the potential protective effects of HRW against chronic ethanol (EtOH)-induced early liver injury and the underlying mechanisms in female mice after chronic-plus-binge EtOH feeding. HRW pretreatment protected against mild EtOH-induced liver injury, possibly by inducing acyl ghrelin to suppress tumor necrosis factor-alpha and interleukin (IL)-6 and induce IL-10 and IL-22, thereby activating antioxidant enzymes against oxidative stress. These results suggest that HRW helps prevent and treat EtOH-induced early liver injury. |
| Publish Date |
2017-07-20 10:12 |
| Citation |
Lin CP, Chuang WC, Lu FJ, Chen CY. Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice. World J Gastroenterol 2017; 23(27): 4920-4934 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i27/4920.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i27.4920 |
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