Publication Name	World Journal of Gastroenterology
Manuscript ID	3375
Country	Australia

Received	2013-04-26 07:51
Peer-Review Started	2013-04-26 19:22
To Make the First Decision	2013-05-14 18:55
Return for Revision	2013-05-18 17:06
Revised	2013-08-04 15:03
Second Decision	2013-09-17 09:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 10:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-19 15:47
Publish the Manuscript Online	2014-05-07 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Prediction of Crohn’s disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort
Manuscript Source	Invited Manuscript
All Author List	Maneesha Bhullar, Finlay Macrae, Gregor Brown, Margie Smith and Ken Sharpe
Funding Agency and Grant Number	Funding Agency Grant Number Schering Plough
Corresponding Author	Maneesha Bhullar, MBBS, MedSc, Department of Colorectal Medicine and Genetics, 3 Centre, The Royal Melbourne Hospital, Grattan St, Parkville 3052, Australia. maneesha.bhullar@mh.org.au
Key Words	Inflammatory bowel disease; Oligomerisation domain 2/caspase recruitment domains 15; Genotyping; Crohn’s disease; Natural history
Core Tip	This study conducted a full gene sequencing of nNucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) within an Australian cohort of patient with Crohn’s disease (CD). In this study, there was a trend to suggest that patients with the 3020insC mutation have a higher frequency of operations compared to those without the mutation. Patients with the 3020insC mutation had a significantly shorter time between the diagnosis of CD and initial surgery. The clinical significance of understanding pathogenic NOD2/CARD15 mutations is to shift management to a top down approach whereby active medical therapy could be introduced at an early stage to impact on aggressive disease behaviour in mutation positive patients.
Publish Date	2014-05-07 10:10
Citation	Bhullar M, Macrae F, Brown G, Smith M, Sharpe K. Prediction of Crohn’s disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort. World J Gastroenterol 2014; 20(17): 5008-5016
URL	http://www.wjgnet.com/1007-9327/full/v20/i17/5008.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i17.5008

Full Article (PDF)	WJG-20-5008.pdf
Full Article (Word)	WJG-20-5008.doc
Manuscript File	3375-Review.docx
Answering Reviewers	3375-Answering reviewers.pdf
Copyright License Agreement	3375-Copyright assignment.pdf
Peer-review Report	3375-Peer review(s).pdf
Scientific Editor Work List	3375-Scientific editor work list.doc