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Articles Published Processes
10/16/2017 7:24:27 AM | Browse: 984 | Download: 1464
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Received |
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2017-03-01 08:37 |
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Peer-Review Started |
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2017-03-03 16:36 |
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To Make the First Decision |
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2017-03-16 13:44 |
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Return for Revision |
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2017-03-20 10:19 |
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Revised |
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2017-04-06 19:12 |
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Second Decision |
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2017-05-27 01:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-06-01 08:53 |
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Articles in Press |
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2017-06-01 08:53 |
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Publication Fee Transferred |
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2017-07-25 11:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-28 08:35 |
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Publish the Manuscript Online |
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2017-10-16 07:24 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Salim Hamdani, Allan Thiolat, Sina Naserian, Cynthia Grondin, Stéphane Moutereau, Anne Hulin, Julien Caldéraro, Philippe Grimbert, José Laurent Cohen, Daniel Azoulay and Caroline Pilon |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Daniel Azoulay, Professor, Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France. daniel.azoulay@aphp.fr |
| Key Words |
Liver transplantation; Myeloid-derived suppressor cells; Rapamycin; Regulatory T cells |
| Core Tip |
Rapamycin is an immunosuppressive drug that is rarely used for liver transplantation treatment due to its side effects. Here, we show that a delayed and short course of rapamycin initiated on day 4 following allogeneic orthotopic liver transplantation in rats resulted in the survival of grafted rats for more than 100 d. The analysis of the cellular compartment revealed an increase in two cellular subpopulations, specifically myeloid-derived suppressor cells and CD8+CD45RClow T cells. The treated liver grafted-rats rejected third-party allogeneic skin grafts, but tolerated skin from syngeneic liver donor rats. Our results identify one of the mechanisms by which the state of tolerance is established. |
| Publish Date |
2017-10-16 07:24 |
| Citation |
Hamdani S, Thiolat A, Naserian S, Grondin C, Moutereau S, Hulin A, Calderaro J, Grimbert P, Cohen JL, Azoulay D, Pilon C. delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats. World J Gastroenterol 2017; 23(38): 6962-6972 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i38/6962.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i38.6962 |
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