Publication Name	World Journal of Hepatology
Manuscript ID	33809
Country	Türkiye

Received	2017-03-05 17:41
Peer-Review Started	2017-03-07 16:51
To Make the First Decision	2017-04-17 09:16
Return for Revision	2017-04-18 15:13
Revised	2017-04-24 23:06
Second Decision	2017-05-11 13:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-19 05:44
Articles in Press	2017-05-19 05:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-31 08:03
Publish the Manuscript Online	2017-06-14 07:52

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver immunology and herbal treatment
Manuscript Source	Invited Manuscript
All Author List	Yasemin H Balaban, Ceylan Aka and Ufuk Koca-Caliskan
Funding Agency and Grant Number
Corresponding Author	Dr. Yasemin H Balaban, Professor, Gastroenterology Unit, Private Etimed Hospital, Elvan Mah, 1934 Sok, No. 4, 06790 Ankara, Turkey. ybalaban@hacettepe.edu.tr
Key Words	Herbal treatments; Hepatic immunology; Drug induced liver injury; Adaptive immunity; Innate immunity
Core Tip	Herbal treatment is the mother of modern medicine. The ancient habit of treating diseases with plants still goes on as either primary or complementary to conventional medical treatment. The other side of medallion is the fact that the liver is number one target organ for herbal toxicity. Furthermore, liver has been recently defined as an active organ of immune system, which have central regulatory role on innate and adaptive immune response. The delicate homeostasis between immediate and efficient defense against threats (immune surveilance of antigens) without triggering harmful immune response towards self-structures (periferal immune tolerance to self antigens) is controled by liver. Herbal formulas are not a single plant extract, but is an interacting mixture of ingredients that determines the final clinical outcome as therapeutic and hepatotoxic effect. This review aimed to drive attention on both potentials of herbals from the point of immunology, in order to initiate a motivation for feature studies defining the mechanisms of immunological interaction between herbals and liver.
Publish Date	2017-06-14 07:52
Citation	Balaban YH, Aka C, Koca-Caliskan U. Liver immunology and herbal treatment. World J Hepatol 2017; 9(17): 757-770
URL	http://www.wjgnet.com/1948-5182/full/v9/i17/757.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i17.757

Full Article (PDF)	WJH-9-757.pdf
Full Article (Word)	WJH-9-757.doc
Manuscript File	33809-Review.doc
Answering Reviewers	33809-Answering reviewers.pdf
Audio Core Tip	33809-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	33809-Conflict-of-interest statement.pdf
Copyright License Agreement	33809-Copyright assignment.pdf
Peer-review Report	33809-Peer-review(s).pdf
Scientific Misconduct Check	33809-Scientific misconduct check.pdf
Scientific Editor Work List	33809-Scientific editor work list.pdf