Publication Name	World Journal of Clinical Oncology
Manuscript ID	33969
Country	Spain

Received	2017-03-21 10:35
Peer-Review Started	2017-03-22 19:46
To Make the First Decision	2017-07-25 00:50
Return for Revision	2017-07-26 01:23
Revised	2017-08-03 11:34
Second Decision	2017-08-25 07:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-09-05 17:26
Articles in Press	2017-09-05 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-13 06:37
Publish the Manuscript Online	2017-09-25 04:24

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory
Manuscript Source	Invited Manuscript
All Author List	Ana García-Casas, Dolores C García-Olmo and Damián García-Olmo
ORCID	Author(s) ORCID Number Ana García-Casas http://orcid.org/0000-0002-1186-8054 Dolores C García-Olmo http://orcid.org/0000-0001-9071-547X Damián García-Olmo http://orcid.org/0000-0002-9369-2338
Funding Agency and Grant Number
Corresponding Author	Damián García-Olmo, Doctor, Doctor, Department of Surgery, Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Avda Reyes Católicos 2, Madrid 28040, Spain. damian.garcia@uam.es
Key Words	Genometastasis; Cancer metastasis; Circulating Nucleic acids: Circulating tumor cells; Liquid biopsy; Exosomes; Virtosomes
Core Tip	Liquid biopsy not only constitutes a promising tool for cancer diagnostic and patient follow-up but also it may help in the comprehension of metastasis. This technique has revealed how circulating tumor cells are limited in blood, while circulating nucleic acids are much more abundant. This property, together with the demonstrated capability of circulating nucleic acids to transform susceptible cells, strongly support the theory of genometastasis. This theory sustains that cancer propagation relies on gene transfer from malignant cells to normal cells. We pretend to gather all these concepts, also including cell-to-cell communication mechanisms to demonstrate this phenomenon.
Publish Date	2017-09-25 04:24
Citation	García-Casas A, García-Olmo DC, García-Olmo D. Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory. World J Clin Oncol 2017; 8(5): 378-388
URL	http://www.wjgnet.com/2218-4333/full/v8/i5/378.htm
DOI	http://dx.doi.org/10.5306/wjco.v8.i5.378

Full Article (PDF)	WJCO-8-378.pdf
Full Article (Word)	WJCO-8-378.doc
Manuscript File	33969-Review.docx
Answering Reviewers	33969-Answering reviewers.pdf
Audio Core Tip	33969-Audio core tip.wav
Conflict-of-Interest Disclosure Form	33969-Conflict-of-interest statement.pdf
Copyright License Agreement	33969-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	33969-Language certificate.pdf
Peer-review Report	33969-Peer-review(s).pdf
Scientific Misconduct Check	33969-Scientific misconduct check.pdf
Scientific Editor Work List	33969-Scientific editor work list.pdf