ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Observational Study |
Article Title |
Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Ryuichi Noguchi, Kosuke Kaji, Tadashi Namisaki, Kei Moriya, Mitsuteru Kitade, Kosuke Takeda, Hideto Kawaratani, Yasushi Okura, Yosuke Aihara, Masanori Furukawa, Akira Mitoro and Hitoshi Yoshiji |
Funding Agency and Grant Number |
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Corresponding Author |
Kosuke Kaji, MD, PhD, Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. kajik@naramed-u.ac.jp |
Key Words |
Angiotensin-converting enzyme; Hepatitis B virus; Liver fibrosis; Noninvasive fibrosis marker; Aspartate aminotransferase-to-platelet ratio index; Fibrosis index based on four factors; Mac-2 binding protein glycosylation isomer |
Core Tip |
Liver fibrosis is one of key factors to determine therapeutic intervention for patients with chronic hepatitis B (CHB). However, the noninvasive prediction of CHB-related liver fibrosis is difficult. Angiotensin-converting enzyme (ACE) is reportedly involved in liver fibrogenesis. In this paper, we demonstrate that serum ACE levels are elevated in patients with CHB and show the predictive potential to diagnose significant fibrosis (≥ F2), which is the therapeutically adapted stage, with higher accuracy as compared with other fibrotic markers including APRI, FIB-4, M2BPGi and Plt. The serum ACE level could be a novel noninvasive marker of significant fibrosis stage in CHB. |
Publish Date |
2017-09-25 08:56 |
Citation |
Noguchi R, Kaji K, Namisaki T, Moriya K, Kitade M, Takeda K, Kawaratani H, Okura Y, Aihara Y, Furukawa M, Mitoro A, Yoshiji H. Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B. World J Gastroenterol 2017; 23(36): 6705-6714 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i36/6705.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i36.6705 |