BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/25/2017 8:56:57 AM | Browse: 834 | Download: 1701
Publication Name World Journal of Gastroenterology
Manuscript ID 34042
Country/Territory Japan
Received
2017-03-23 16:57
Peer-Review Started
2017-03-23 19:29
To Make the First Decision
2017-04-21 10:01
Return for Revision
2017-04-28 10:57
Revised
2017-05-01 20:09
Second Decision
2017-06-16 12:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-19 08:44
Articles in Press
2017-06-19 08:44
Publication Fee Transferred
2017-06-20 03:26
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-12 08:03
Publish the Manuscript Online
2017-09-25 08:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B
Manuscript Source Unsolicited Manuscript
All Author List Ryuichi Noguchi, Kosuke Kaji, Tadashi Namisaki, Kei Moriya, Mitsuteru Kitade, Kosuke Takeda, Hideto Kawaratani, Yasushi Okura, Yosuke Aihara, Masanori Furukawa, Akira Mitoro and Hitoshi Yoshiji
Funding Agency and Grant Number
Corresponding Author Kosuke Kaji, MD, PhD, Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. kajik@naramed-u.ac.jp
Key Words Angiotensin-converting enzyme; Hepatitis B virus; Liver fibrosis; Noninvasive fibrosis marker; Aspartate aminotransferase-to-platelet ratio index; Fibrosis index based on four factors; Mac-2 binding protein glycosylation isomer
Core Tip Liver fibrosis is one of key factors to determine therapeutic intervention for patients with chronic hepatitis B (CHB). However, the noninvasive prediction of CHB-related liver fibrosis is difficult. Angiotensin-converting enzyme (ACE) is reportedly involved in liver fibrogenesis. In this paper, we demonstrate that serum ACE levels are elevated in patients with CHB and show the predictive potential to diagnose significant fibrosis (≥ F2), which is the therapeutically adapted stage, with higher accuracy as compared with other fibrotic markers including APRI, FIB-4, M2BPGi and Plt. The serum ACE level could be a novel noninvasive marker of significant fibrosis stage in CHB.
Publish Date 2017-09-25 08:56
Citation Noguchi R, Kaji K, Namisaki T, Moriya K, Kitade M, Takeda K, Kawaratani H, Okura Y, Aihara Y, Furukawa M, Mitoro A, Yoshiji H. Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B. World J Gastroenterol 2017; 23(36): 6705-6714
URL http://www.wjgnet.com/1007-9327/full/v23/i36/6705.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i36.6705
Full Article (PDF) WJG-23-6705.pdf
Full Article (Word) WJG-23-6705.doc
Manuscript File 34042-Review.docx
Answering Reviewers 34042-Answering reviewers.pdf
Audio Core Tip 34042-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 34042-Conflict-of-interest statement.pdf
Copyright License Agreement 34042-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 34042-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 34042-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34042-Language certificate.pdf
Supplementary Material 34042-Supplementary material.pdf
Peer-review Report 34042-Peer-review(s).pdf
Scientific Misconduct Check 34042-Scientific misconduct check.pdf
Scientific Editor Work List 34042-Scientific editor work list.pdf