Publication Name	World Journal of Gastroenterology
Manuscript ID	34207
Country	United States

Received	2017-04-10 13:48
Peer-Review Started	2017-04-11 10:21
To Make the First Decision	2017-04-21 09:36
Return for Revision	2017-04-24 16:04
Revised	2017-05-04 03:31
Second Decision	2017-06-12 05:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-06-19 09:18
Articles in Press	2017-06-19 09:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-02 07:35
Publish the Manuscript Online	2017-08-14 04:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Systematic review of giant gastric lipomas reported since 1980 and report of two new cases in a review of 117110 esophagogastroduodenoscopies
Manuscript Source	Invited Manuscript
All Author List	Mitchell S Cappell, Charlton E Stevens and Mitual Amin
ORCID	Author(s) ORCID Number Mitchell S Cappell http://orcid.org/0000-0003-3445-5428 Charlton E Stevens http://orcid.org/0000-0002-9036-1146 Mitual Amin http://orcid.org/0000-0002-0558-2615
Funding Agency and Grant Number
Corresponding Author	Mitchell S Cappell, MD, PhD, Chief Doctor, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB #602, 3535 W. Thirteen Mile Rd, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Key Words	Esophagogastroduodenoscopy Lipoma; Gastric; Giant; Melena; Upper gastrointestinal bleeding; Systematic review
Core Tip	Systematic literature review of giant ga­stric lipomas revealed 32 reported cases since 1980, with 2 new cases reported among 117110 esophagogastroduodenoscopies. Two authors inde­pendently reviewed literature, and decided by consensus which articles to incorporate. Average-patient-age = 54.5 ± 17.0 years (males = 68.8%). Mean-maximal-lipoma-diameter = 7.9 cm ± 4.1 cm. Lipoma locations: antrum-17, antrum and other gastric segments-7, other-8. Lipomas were submucosal-92%, subserosal-8%. Presentations included: acute up­per gastrointestinal (UGI) bleeding-19, abdominal pain-5, nausea/vomiting-5, asymptomatic-3. esop­hagogastroduodenoscopy was extremely helpful diagnostically; findings included: yellowish hue, well-demarcated margins, and smooth overlying mucosa. Endoscopic biopsies were infrequently diagnostic. Twenty of 21 abdominal CTs demonstrated characteristic lipoma findings: well-circumscribed, submucosal, and homogeneous mass with fat attenuation. Endoscopic-ultrasound showed characteristic findings in 80%. All patients underwent successful therapy without major complications/mortality, including: laparotomy-with-full-thickness-gastric-wall-resections-26; and other-6. Two newly reported patients presented with severe UGI bleeding from giant, ulcerated, gastric lipomas. This review may help standardize work-up of these patients.
Publish Date	2017-08-14 04:00
Citation	Cappell MS, Stevens CE, Amin M. Systematic review of giant gastric lipomas reported since 1980 and report of two new cases in a review of 117110 esophagogastroduodenoscopies. World J Gastroenterol 2017; 23(30): 5619-5633
URL	http://www.wjgnet.com/1007-9327/full/v23/i30/5619.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i30.5619

Full Article (PDF)	WJG-23-5619.pdf
Full Article (Word)	WJG-23-5619.doc
Manuscript File	34207-Review.docx
Answering Reviewers	34207-Answering reviewers.pdf
Audio Core Tip	34207-Audio core tip.mp3
Biostatistics Review Certificate	34207-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	34207-Conflict-of-interest statement.pdf
Copyright License Agreement	34207-Copyright assignment.pdf
Supplementary Material	34207_Giantgastriclipoma-IRBapprovalexemption.docx
Peer-review Report	34207-Peer-review(s).pdf
Scientific Misconduct Check	34207-Scientific misconduct check.pdf
Scientific Editor Work List	34207-Scientific editor work list.pdf