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Articles Published Processes
7/28/2017 8:16:18 AM | Browse: 1054 | Download: 2168
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Received |
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2017-04-14 08:48 |
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Peer-Review Started |
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2017-04-18 08:07 |
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To Make the First Decision |
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2017-05-12 09:26 |
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Return for Revision |
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2017-05-16 09:15 |
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Revised |
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2017-05-24 07:09 |
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Second Decision |
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2017-06-27 00:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-07-04 06:15 |
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Articles in Press |
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2017-07-04 06:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-07-09 02:34 |
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Typeset the Manuscript |
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2017-07-19 02:33 |
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Publish the Manuscript Online |
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2017-07-28 08:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Single amino acid mutation of SR-BI decreases infectivity of hepatitis C virus derived from cell culture in a cell culture model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rong Gao, Wei Gao, Gang Xu, Jie Xu and Hao Ren |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31370196 |
| National 973 Program |
2013CB53160 |
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| Corresponding Author |
Hao Ren, Professor, Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China. renh@smmu.edu.cn |
| Key Words |
Hepatitis C virus; Class B scavenger receptor I; Mutant; Infectivity |
| Core Tip |
Human class B scavenger receptor I (SR-BI) plays important roles in both host lipid metabolism and the entry of hepatitis C virus (HCV). Single nucleotide polymorphisms (SNPs) in the host genome that affect the virus-host interaction have received increasing attention in recent years. Several SR-BI SNPs have been reported to affect the high-density lipoprotein cholesterol levels in populations carrying SR-BI mutations; however, the impact of SR-BI SNPs on HCV infection has not been studied intensively. Based on our results, the S112F single amino acid mutation in SR-BI inhibited the infectivity of hepatitis C virus derived from cell culture in a cell culture model by downregulating the expression of the SR-BI protein. |
| Publish Date |
2017-07-28 08:16 |
| Citation |
Gao R, Gao W, Xu G, Xu J, Ren H. Single amino acid mutation of SR-BI decreases infectivity of hepatitis C virus derived from cell culture in a cell culture model. World J Gastroenterol 2017; 23(28): 5158-5166 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i28/5158.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i28.5158 |
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