Publication Name	World Journal of Gastroenterology
Manuscript ID	34441
Country	Netherlands

Received	2017-04-25 09:55
Peer-Review Started	2017-04-25 14:22
To Make the First Decision	2017-05-12 08:47
Return for Revision	2017-05-16 02:37
Revised	2017-08-08 19:05
Second Decision	2017-08-15 06:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-08-15 15:18
Articles in Press	2017-08-15 15:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-15 01:30
Publish the Manuscript Online	2017-12-27 11:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Human small intestine is capable of restoring barrier function after short ischemic periods
Manuscript Source	Unsolicited Manuscript
All Author List	Dirk HSM Schellekens, Inca HR Hundscheid, Joep Grootjans, Kaatje Lenaerts, Wim A Buurman, Cornelis HC Dejong and Joep PM Derikx
ORCID	Author(s) ORCID Number Dirk HSM Schellekens http://orcid.org/0000-0002-3644-7811 Inca HR Hundscheid http://orcid.org/0000-0003-2337-3718 Joep Grootjans http://orcid.org/0000-0003-0179-4255 Kaatje Lenaerts http://orcid.org/0000-0002-9858-0538 Wim A Buurman http://orcid.org/0000-0002-5884-6223 Cornelis HC Dejong http://orcid.org/0000-0003-1824-7303 Joep PM Derikx http://orcid.org/0000-0003-0694-7679
Funding Agency and Grant Number	Funding Agency Grant Number Dutch Digestive Foundation MLDS grant WO10-57 Dutch Digestive Foundation to Derikx JPM MLDS Career development grant CDG13-14 the Netherlands Organisation for Scientific Research Rubicon grant 2013/07161/ALW to J Grootjans
Corresponding Author	Dirk HSM Schellekens, MD, Department of Surgery, Maastricht University Medical Center, Maastricht, PO Box 616, MD 6200, Netherlands. d.schellekens@maastrichtuniversity.nl
Key Words	Intestinal ischemia-reperfusion; Intestinal barrier function; Intestinal permeability; Human; Dual-sugar absorption test; Tight Junctions; Citrulline
Core Tip	Using an unique experiment human intestinal ischemia and reperfusion (IR) model, this is the first study to directly correlate histological data with intestinal permeability tests. The results reveal the ability of the intestine to withstand short episodes of ischemia, with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion. These results explain why there are often no signs of inflammation or bacterial translocation after short periods of intestinal ischemia. Exploration of the mechanisms responsible for this rapid recovery might impact understanding and treatment of intestinal diseases. Data from the dual-sugar absorption tests and citrulline reflect the histological perturbations during intestinal IR, highlighting the potential diagnostic value of these tests in patients with intestinal diseases associated with intestinal barrier loss.
Publish Date	2017-12-27 11:08
Citation	Schellekens DH, Hundscheid IH, Leenarts CA, Grootjans J, Lenaerts K, Buurman WA, Dejong CH, Derikx JP. Human small intestine is capable of restoring barrier function after short ischemic periods. World J Gastroenterol 2017; 23(48): 8452-8464
URL	http://www.wjgnet.com/1007-9327/full/v23/i48/8452.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i48.8452

Full Article (PDF)	WJG-23-8452.pdf
Full Article (Word)	WJG-23-8452.doc
Manuscript File	34441-Review.doc
Answering Reviewers	34441-Answering reviewers.pdf
Audio Core Tip	34441-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	34441-Conflict-of-interest statement.pdf
Copyright License Agreement	34441-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	34441-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	34441-Institutional review board statement.pdf
Supplementary Material	34441-Supplementary-Material-revision.doc
Peer-review Report	34441-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	34441-Scientific misconduct check.pdf
Scientific Editor Work List	34441-Scientific editor work list.pdf