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11/12/2017 6:39:43 AM | Browse: 309 | Download: 257
Publication Name World Journal of Gastroenterology
Manuscript ID 35116
Country of Manuscript Source Japan
Received
2017-06-24 10:38
Peer-Review Started
2017-06-26 08:16
To Make the First Decision
2017-07-13 05:25
Return for Revision
2017-07-17 02:33
Revised
2017-07-31 08:27
Second Decision
2017-08-30 02:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-05 18:34
Articles in Press
2017-09-05 18:34
Publication Fee Transferred
2017-09-28 05:34
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-11-06 04:39
Publish the Manuscript Online
2017-11-12 06:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Medicine, Research and Experimental
Manuscript type Basic Study
Article Title Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor
Manuscript Source Unsolicited Manuscript
All Author List Winn Aung, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Yoshinori Ukai, Katsushi Kouda, Yoshikazu Kurosawa, Takako Furukawa, Tsuneo Saga and Tatsuya Higashi
ORCID
Author(s) ORCID Number
Winn Aung http://orcid.org/orcid.org/0000-0002-0896-7158
Atsushi B Tsuji http://orcid.org/orcid.org/0000-0003-2726-288X
Hitomi Sudo http://orcid.org/orcid.org/0000-0001-5012-6435
Aya Sugyo http://orcid.org/orcid.org/0000-0002-5174-4478
Yoshinori Ukai http://orcid.org/orcid.org/0000-0001-7661-7777
Katsushi Kouda http://orcid.org/orcid.org/0000-0003-3608-0156
Yoshikazu Kurosawa http://orcid.org/orcid.org/0000-0002-0472-5418
Takako Furukawa http://orcid.org/orcid.org/0000-0002-4617-7173
Tsuneo Saga http://orcid.org/orcid.org/0000-0001-7801-9316
Tatsuya Higashi http://orcid.org/orcid.org/0000-0002-8338-4737
Funding Agency and Grant Number
Funding Agency Grant Number
(Partially) Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology, Japan 17K10460 to Aung W
Correspondence To Winn Aung, MBBS, PhD, Senior Research Fellow, Senior Researcher, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. winn.aung@qst.go.jp
Keywords Radioimmunotherapy; Pancreatic cancer; Anti-integrin α6β4 antibody; Yttrium-90; NVP-BEZ235
Core Tip We examined whether the therapeutic effect of 90Y-labeled anti-α6β4 integrin antibody (ITGA6B4)-mediated radioimmunotherapy (RIT) is improved by dual PI3K/mTOR inhibitor BEZ235 in the treatment of pancreatic cancer xenograft. There is no report about the combined therapeutic effects of RIT and BEZ235 in cancer treatment, though BEZ235 has been tested for its anticancer and potential radiosensitizing effect. Our studies (in vitro/in vivo) and results suggest for the first time that it is possible to improve the therapeutic efficacy by combining 90Y-ITGA6B4-RIT and BEZ235 and this combination can be a potential encouraging treatment modality in the future.
Publish Date 2017-11-12 06:39
Citation Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T, Higashi T. Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor. World J Gastroenterol 2017; 23(42): 7551-7562
Url http://www.wjgnet.com/1007-9327/full/v23/i42/7551.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i42.7551
Full Article (PDF) WJG-23-7551.pdf
Full Article (Word) WJG-23-7551.doc
Manuscript File 35116-Review.docx
Answering Reviewers 35116-Answering reviewers.pdf
Audio Core Tip 35116-Audio core tip.mp3
Biostatistics Review Certificate 35116-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 35116-Conflict-of-interest statement.pdf
Copyright License Agreement 35116-Copyright assignment.pdf
Data Sharing Statement 35116-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35116-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 35116-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 35116-Institutional-Review-Board-Statement-revision.pdf
Non-Native Speakers of English Editing Certificate 35116-Language certificate.pdf
Scientific Research Process 35116-Scientific research process.pdf
Peer-review Report 35116-Peer-review(s).pdf
Scientific Misconduct Check 35116-Scientific misconduct check.pdf
Scientific Editor Work List 35116-Scientific editor work list.pdf