Publication Name	World Journal of Gastroenterology
Manuscript ID	35148
Country	United States

Received	2017-06-23 01:17
Peer-Review Started	2017-06-24 09:09
To Make the First Decision	2017-07-13 05:25
Return for Revision	2017-07-17 01:06
Revised	2017-07-30 09:25
Second Decision	2017-08-21 04:32
Accepted by Journal Editor-in-Chief	2017-08-21 06:17
Accepted by Executive Editor-in-Chief	2017-08-25 14:24
Articles in Press	2017-08-25 14:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-09-25 12:23
Publish the Manuscript Online	2017-09-28 10:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Microbial dysbiosis in spouses of ulcerative colitis patients: Any clues to disease pathogenesis?
Manuscript Source	Invited Manuscript
All Author List	Dario Sorrentino
ORCID	Author(s) ORCID Number Dario Sorrentino http://orcid.org/0000-0002-2694-8823
Funding Agency and Grant Number
Corresponding Author	Dario Sorrentino, MD, Professor, IBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, Roanoke, VA 24018, United States. drsorrentino@carilionclinic.org
Key Words	Ulcerative colitis; Cohabitation; Spouses; Gut microbiome
Core Tip	Dysbiosis in inflammatory bowel diseases is common. However, microbial dysbiosis could be a consequence, rather than cause of the disease state. In this study the authors detected dysbiosis and altered microbial metabolism not only in ulcerative colitis patients but also in their healthy cohabiting partners. Therefore, the microbiome might be partially transferred from ulcerative colitis patients to healthy individuals. Since spouses of ulcerative colitis patients do not have an increased risk of developing the disease this study suggests that dysbiosis might be an effect rather than the cause of the disease. Overall, the precise role of the microbiome on inflammatory bowel disease etiology remains unknown.
Publish Date	2017-09-28 10:01
Citation	Sorrentino D. Microbial dysbiosis in spouses of ulcerative colitis patients: Any clues to disease pathogenesis? World J Gastroenterol 2017; 23(37): 6747-6749
URL	http://www.wjgnet.com/1007-9327/full/v23/i37/6747.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i37.6747

Full Article (PDF)	WJG-23-6747.pdf
Full Article (Word)	WJG-23-6747.doc
Manuscript File	35148-Review.docx
Answering Reviewers	35148-Answering reviewers.pdf
Audio Core Tip	35148-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	35148-Conflict-of-interest statement.pdf
Copyright License Agreement	35148-Copyright assignment.pdf
Peer-review Report	35148-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	35148-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	35148-Scientific misconduct check.pdf
Scientific Editor Work List	35148-Scientific editor work list.pdf