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Articles Published Processes
9/26/2017 12:18:54 AM | Browse: 2092 | Download: 2499
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Received |
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2017-07-15 05:04 |
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Peer-Review Started |
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2017-07-18 05:58 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2017-08-11 07:45 |
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Revised |
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2017-08-21 11:31 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-08-30 02:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-09-05 18:27 |
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Articles in Press |
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2017-09-05 18:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-09-24 02:40 |
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Publish the Manuscript Online |
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2017-09-25 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Nonalcoholic fatty liver disease: Evolving paradigms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi and Luigi Elio Adinolfi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Luigi Elio Adinolfi, MD, Full Professor, Department of Medical, Surgical, Neurological, Geriatric, and Metabolic Sciences, University of Campania “Luigi Vanvitelli, Piazza Miraglia, Naples 80100, Italy. luigielio.adinolfi@unicampania.it |
| Key Words |
Nonalcoholic fatty liver disease; Biomarkers; Clinical correlates; Diagnosis; Epidemiology; Genetics; Liver histology; Management; Metabolic Syndrome; Pathogenesis; Screening; Type 2 diabetes |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is a pandemic disease. Recent evidence highlights new concepts in clinical and pathogenic heterogeneity of NAFLD, a systemic disorder with a multifactorial pathogenesis and protean clinical manifestations. Other than the classical obese phenotype of NAFLD, a lean though metabolically abnormal variant has been recognized. Simple steatosis is no more considered a benign condition; insulin resistance is necessary but not sufficient for the disease progression, and NAFLD is not only a mere hepatic manifestation of metabolic syndrome, but may forerun the development of metabolic syndrome and cardio-renal complications. Several non-invasive diagnostic tests are now available and new drug treatment options are coming. |
| Publish Date |
2017-09-25 08:56 |
| Citation |
Lonardo A, Nascimbeni F, Maurantonio M, Marrazzo A, Rinaldi L, Adinolfi LE. Nonalcoholic fatty liver disease: Evolving paradigms. World J Gastroenterol 2017; 23(36): 6571-6592 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i36/6571.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i36.6571 |
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