Publication Name	World Journal of Gastroenterology
Manuscript ID	3538
Country	China

Received	2013-05-05 15:08
Peer-Review Started	2013-05-06 10:36
To Make the First Decision	2013-05-23 17:15
Return for Revision	2013-06-02 20:12
Revised	2013-07-24 22:47
Second Decision	2013-08-06 08:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 11:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-22 10:45
Publish the Manuscript Online	2013-09-21 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Autobiography
Article Title	Influence of chronic HBV infection on superimposed acute hepatitis E
Manuscript Source	Invited Manuscript
All Author List	Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li and Qi-Huan Xu
Funding Agency and Grant Number
Corresponding Author	Qi-Huan Xu, Professor, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou 510630, Guangdong Province, China. xqh03030513@aliyun.com
Key Words	Chronic hepatitis B virus infection; Acute hepatitis E; Superinfection; Clinical profile; Anti-hepatitis B virus treatment
Core Tip	Previous studies have shown that chronic hepatitis B virus (HBV) infection has a negative impact on superimposed acute hepatitis E. However, it remains unknown whether the disease severity of acute hepatitis E correlates with the underlying HBV replication status or with liver histological lesions. Our study showed that the disease severity of acute hepatitis E correlated not with the HBV replication status (based on the status of hepatitis B e antigen and HBV DNA), but rather with the presence of underlying cirrhosis. This finding raised the question of whether anti-HBV treatment improves the outcome of liver failure caused by HBV-hepatitis E virus superinfection. We found that anti-HBV treatment could not improve the prognosis of such liver failure.
Publish Date	2013-09-21 09:08
Citation	Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM, Li G, Xu QH. Influence of chronic HBV infection on superimposed acute hepatitis E. World J Gastroenterol 2013; 19(35): 5904-5909
URL	http://www.wjgnet.com/1007-9327/full/v19/i35/5904.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i35.5904

Full Article (PDF)	WJG-19-5904.pdf
Manuscript File	3538-Review.docx
Answering Reviewers	3538-Answering reviewers.pdf
Copyright License Agreement	3538-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3538-Language certificate.pdf
Peer-review Report	3538-Peer review(s).pdf
Scientific Editor Work List	3538-Scientific editor work list.doc