Publication Name	World Journal of Otorhinolaryngology
Manuscript ID	3546
Country	Finland

Received	2013-05-05 17:23
Peer-Review Started	2013-05-05 20:15
To Make the First Decision	2013-06-24 10:25
Return for Revision	2013-07-04 13:52
Revised	2013-08-22 23:24
Second Decision	2013-10-17 13:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-18 07:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-06 15:25
Publish the Manuscript Online	2013-12-03 15:38

ISSN	2218-6247 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Otorhinolaryngology
Manuscript Type	Review
Article Title	Nanoparticle based inner ear therapy
Manuscript Source	Invited Manuscript
All Author List	Ilmari Pyykkö, Jing Zou, Ya Zhang, Weikai Zhang, Hao Feng and Paavo Kinnunen
Funding Agency and Grant Number	Funding Agency Grant Number EU Nanoear Integrated Project NMP4-CT-2006-026556 EU NanoCI Collaborative Project FP7 281056
Corresponding Author	Ilmari Pyykk? Department of otolaryngology Hearing and Balance Research Unit University of Tampere Teiskontie 35, M-building Room 318 Tampere 33520, Finland e-mail ilmari.pyykko@uta.fi
Key Words	Synthetic vector; Gene delivery; shRNA delivery; Targeted cochlear therapy; Minimally invasive therapy
Core Tip	Several novel, multifunctional nanoparticles have been developed, which are targetable to selected tissue, biodegradable, traceable in vivo, and equipped with controlled payload release. They can be used to transport therapeutic agents, such as drugs, genes, small interfering RNAs and growth factors into the inner ear. To visualise the targetability and accuracy of the delivery, the nanoparticles can be traced with magnetic resonance imaging. It is hoped that this technology will come to be used as an alternative carrier to viral vectors traditionally used in gene delivery, but without the severe adverse effect.
Publish Date	2013-12-03 15:38
Citation	Pyykk? I, Zou J, ZhangY, Zhang W, Feng H, Kinnunen P. Nanoparticle based inner ear therapy. World J Otorhinolaryngol 2013; 3(4): 114-133
URL	http://www.wjgnet.com/2218-6247/full/v3/i4/114.htm
DOI	http://dx.doi.org/10.5319/wjo.v3.i4.114

Full Article (PDF)	WJO-3-114.pdf
Manuscript File	3546-Review.docx
Answering Reviewers	3546-Answering reviewers.pdf
Copyright License Agreement	3546-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3546-Language certificate.pdf
Peer-review Report	3546-Peer reviews.pdf
Scientific Editor Work List	3546-Scientific editor work list.doc