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12/20/2017 2:49:19 AM | Browse: 247 | Download: 112
Publication Name World Journal of Gastroenterology
Manuscript ID 35607
Country of Manuscript Source Taiwan
2017-07-28 00:39
Peer-Review Started
2017-07-28 02:04
To Make the First Decision
2017-08-30 03:23
Return for Revision
2017-09-04 07:21
2017-09-19 13:38
Second Decision
2017-09-25 06:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-26 01:44
Articles in Press
2017-09-26 01:44
Publication Fee Transferred
2017-09-29 15:02
Edit the Manuscript by Language Editor
2017-12-05 06:58
Typeset the Manuscript
2017-12-09 07:15
Publish the Manuscript Online
2017-12-20 02:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Clinical Trials Study
Article Title First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease
Manuscript Source Unsolicited Manuscript
All Author List Chih-Ming Liang, Ming-Te Kuo, Ping-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Hsin-Ming Wang, Chih-Chien Yao, Cheng-En Tsai, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Deng-Chyang Wu and Seng-Kee Chuah
Author(s) ORCID Number
Chih-Ming Liang http://orcid.org/0000-0002-6614-5937
Ming-Te Kuo http://orcid.org/0000-0001-9223-918X
Ping-I Hsu http://orcid.org/0000-0003-3905-4674
Chao-Hung Kuo http://orcid.org/0000-0003-1847-395x
Wei-Chen Tai http://orcid.org/0000-0002-8026-1408
Shih-Cheng Yang http://orcid.org/0000-0002-8288-8845
Keng-Liang Wu http://orcid.org/0000-0002-8703-6625
Hsin-Ming Wang http://orcid.org/0000-0002-2599-6495
Chih-Chien Yao http://orcid.org/0000-0002-4868-200X
Cheng-En Tsai http://orcid.org/orcid.org/0000-0001-9840-4051
Yao-Kuang Wang http://orcid.org/0000-0002-5536-7542
Jiunn-Wei Wang http://orcid.org/0000-0003-2534-438x
Chih-Fang Huang http://orcid.org/orcid.org/0000-0002-5900-292X
Deng-Chyang Wu http://orcid.org/0000-0003-3742-0634
Seng-Kee Chuah http://orcid.org/0000-0002-8934-3223
Funding Agency and Grant Number
Funding Agency Grant Number
Research Foundation of Chang Gung Memorial Hospital (CMRPG8D1441), Taiwan
Correspondence To Seng-Kee Chuah, MD, Chief Doctor, Professor, Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan. chuahsk@cmgh.org.tw
Keywords Dexlansoprazole; Esomeprazole; One-week response; Complete symptom resolution rate; Gastroesophageal reflux disease
Core Tip No existing report has investigated the short-term clinical effects of dexlansoprazole 60 mg vs esomeprazole 40 mg. This study compared the one-week clinical effects of a single dose of the two drugs for grades A and B erosive esophagitis. We enrolled 175 adult patients with gastroesophageal reflux disease (GERD) and randomized them in a 1:1 ratio into a dexlansoprazole (n = 88) or esomeprazole group (n = 87) for an intention-to-treat analysis (ITT). The primary end-points were the complete symptom resolution (CSR) rates at days 1, 3, and 7. The CSRs for both groups were similar at days 1, 3 and 7. In the subgroup analysis, female patients achieved higher CSRs in the dexlansoprazole group than in the esomeprazole group at day 3 (38.3% vs 18.4%, p = 0.046). In the esomeprazole group, female sex was a negative predictive factor for CSR at post-dose day 1 [OR = -1.249 ± 0.543; 95%CI: 0.287 (0.099-0.832), p = 0.022] and day 3 [OR = -1.254 ± 0.519; 95%CI: 0.285 (0.103-0.789), p = 0.016]. This pilot study suggested that the overall CSR rates for GERD patients were similar at days 1 through 7 for both the dexlansoprazole and esomeprazole groups, although a higher CSR was observed at day 3 in female patients who received a single dose of dexlansoprazole.
Publish Date 2017-12-20 02:49
Citation Liang CM, Kuo MT, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Wang HM, Yao CC, Tsai CE, Wang YK, Wang JW, Huang CF, Wu DC, Chuah SK; Taiwan Acid-Related Disease Study Group. First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease. World J Gastroenterol 2017; 23(47): 8395-8404
Url http://www.wjgnet.com/1007-9327/full/v23/i47/8395.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i47.8395
Full Article (PDF) WJG-23-8395.pdf
Full Article (Word) WJG-23-8395.doc
Manuscript File 35607-Review.doc
Answering Reviewers 35607-Answering reviewers.pdf
Audio Core Tip 35607-Audio core tip.mp3
Clinical Trial Registration Statement 35607-Clinical trial registration.pdf
Conflict-of-Interest Disclosure Form 35607-Conflict-of-interest statement.pdf
Copyright License Agreement 35607-Copyright assignment.pdf
Data Sharing Statement 35607-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 35607-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 35607-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 35607-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 35607-Language certificate.pdf
Peer-review Report 35607-Peer-review(s).pdf
Scientific Misconduct Check 35607-Scientific misconduct check.pdf
Scientific Editor Work List 35607-Scientific editor work list.pdf