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Articles Published Processes
12/27/2017 11:08:08 AM | Browse: 1198 | Download: 1831
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Received |
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2017-07-30 03:16 |
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Peer-Review Started |
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2017-07-30 15:19 |
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To Make the First Decision |
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2017-08-30 03:18 |
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Return for Revision |
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2017-09-04 07:19 |
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Revised |
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2017-10-09 15:20 |
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Second Decision |
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2017-11-07 08:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-07 18:30 |
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Articles in Press |
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2017-11-07 18:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-11-16 01:01 |
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Publish the Manuscript Online |
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2017-12-27 11:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Fusobacterium’s link to colorectal neoplasia sequenced: A systematic review and future insights
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hisham Hussan, Steven K Clinton, Kristen Roberts and Michael T Bailey |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hisham Hussan, MD, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Suite 240, Columbus, OH 43210, United States. hisham.hussan@osumc.edu |
| Key Words |
Colon microbiota; Fusobacterium; Fusobacterium nucleatum; Colorectal cancer; Colorectal polyps; Carcinogenesis; Systematic; Review |
| Core Tip |
This is, to our knowledge, the first review to systematically examine the heterogeneous literature linking Fusobacterium to colorectal neoplasia. Accumulating evidence suggests that Fusobacterium, specifically Fusobacterium nucleatum (F. nucleatum), is more frequently detected in colorectal neoplasia, especially the pathway involving microsatellite instability. Multiple observational and animal experimental studies also suggest a procarcinogenic effect of F. nucleatum, likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. Virulence factors of F. nucleatum may contribute to its procarcinogenic effect. This information may be used to create novel strategies targeting colorectal cancer detection and chemoprevention. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Hussan H, Clinton SK, Roberts K, Bailey MT. Fusobacterium’s link to colorectal neoplasia sequenced: a systematic review and future insights. World J Gastroenterol 2017; 23(48): 8626-8650 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8626.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8626 |
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