Publication Name	World Journal of Virology
Manuscript ID	3569
Country	Portugal

Received	2013-05-07 08:37
Peer-Review Started	2013-05-07 11:20
To Make the First Decision	2013-07-05 18:31
Return for Revision	2013-07-17 10:35
Revised	2013-07-26 22:57
Second Decision	2013-08-08 19:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-09 01:10
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-15 11:05
Publish the Manuscript Online	2013-08-26 14:05

ISSN	2220-3249 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Autobiography
Article Title	Searching for nuclear export elements in hepatitis D virus RNA
Manuscript Source	Invited Manuscript
All Author List	Natália Freitas and Celso Cunha
Funding Agency and Grant Number	Funding Agency Grant Number Fundação para a Ciência e Tecnologia, Portugal to Freitas N
Corresponding Author	Celso Cunha, PhD, Medical Microbiology Unit, Center for Malaria and Tropical Diseases, Institute of Hygiene and Tropical Medicine, Nova University of Lisbon, Rua da Junqueira, 100, 1349-008 Lisbon, Portugal. ccunha@ihmt.unl.pt
Key Words	Hepatitis D virus; Genomic RNA; Antigenomic RNA; Nuclear export; Nuclear export element
Core Tip	Hepatitis D virus (HDV) replicates in the nucleus and export of HDV RNPs to the cytoplasm is thought to be mediated by cis-elements present in virus RNA. We used a chloramphenicol acetyl-transferase reporter system in an attempt to identify the RNA sequences that mediate export to the cytoplasm. Several cDNA constructs coding for different HDV RNA (genomic and antigenomic) sequences were tested. Our results show that a cis-acting nuclear export element is present in positions 214-417 of antigenomic RNA. Two regions in genomic RNA were found to promote nuclear export with efficiency higher than the negative control although lower that the positive control.
Publish Date	2013-08-26 14:05
Citation	Freitas N, Cunha C. Searching for nuclear export elements in hepatitis D virus RNA. World J Virol 2013; 2(3): 123-135
URL	http://www.wjgnet.com/2220-3249/full/v2/i3/23.htm
DOI	http://dx.doi.org/10.5501/wjv.v2.i3.123

Full Article (PDF)	WJV-2-123.pdf
Manuscript File	3569-Review.docx
Answering Reviewers	3569-Answering reviewers.pdf
Copyright License Agreement	3569-Copyright assignment.pdf
Peer-review Report	3569-Peer review(s).pdf
Scientific Editor Work List	3569-Scientific editor work list.doc