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Articles Published Processes
10/29/2017 6:01:44 AM | Browse: 1024 | Download: 1244
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Received |
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2017-08-22 01:26 |
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Peer-Review Started |
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2017-08-22 05:09 |
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To Make the First Decision |
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2017-09-20 01:11 |
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Return for Revision |
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2017-09-21 04:05 |
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Revised |
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2017-09-25 12:08 |
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Second Decision |
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2017-10-17 08:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-10-17 20:08 |
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Articles in Press |
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2017-10-17 20:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-10-23 03:17 |
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Publish the Manuscript Online |
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2017-10-29 06:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
S -Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S -Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dimitrios Tsikas, Erik Hanff and Alexander Bollenbach |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dimitrios Tsikas, Professor, Core Unit Proteomics, Centre of Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany. tsikas.dimitros@mh-hannover.de |
| Key Words |
S-Adenosyl-L-methionine; Bioavailability; Concentration; Liver |
| Core Tip |
S-Adenosyl-L-methionine (SAM) serves as a cofactor for enzymes that transfer its methyl group to nucleophilic functionalities of various biomolecules including DNA and RNA. Exogenous SAM has been shown to be a useful pharmacological agent in liver-associated diseases. SAM is a labile species, undergoes spontaneous decomposition in biological samples, and its oral bioavailability is only about 2%. Lozano-Sepulveda and colleagues observed that SAM modulates antioxidant enzymes, restores glutathione synthesis, and switches MAT1/MAT2 turnover in hepatitis C virus (HCV) expressing cells. The authors suggested that this may be a likely mechanism by which HCV expression is diminished by SAM. This SAM concentration range was chosen on the basis of cell viability experiments and is up to 1000 times higher than physiological intracellular. Other groups have used SAM in the concentration range 0-1000 nmol/L. The efficacy of SAM, its pharmacological effects towards HCV and possibly adverse effects beyond cell viability need to be elaborated in further studies using SAM concentrations much lower than 1 mmol/L. |
| Publish Date |
2017-10-29 06:01 |
| Citation |
Tsikas D, Hanff E, Bollenbach A. S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics. World J Gastroenterol 2017; 23(40): 7343-7346 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i40/7343.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i40.7343 |
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