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12/27/2017 10:31:19 AM | Browse: 968 | Download: 1299
Publication Name World Journal of Hepatology
Manuscript ID 36026
Country Belgium
Received
2017-09-25 00:39
Peer-Review Started
2017-09-25 05:47
To Make the First Decision
2017-10-09 07:12
Return for Revision
2017-10-09 09:14
Revised
2017-11-20 09:25
Second Decision
2017-11-28 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-12-05 23:25
Articles in Press
2017-12-05 23:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-12-26 01:01
Publish the Manuscript Online
2017-12-27 10:31
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Sequential tumor-directed and lobar radioembolization before major hepatectomy for hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Michael Vouche, Thierry Degrez, Fikri Bouazza, Philippe Delatte, Maria Gomez Galdon, Alain Hendlisz, Patrick Flamen and Vincent Donckier
ORCID
Author(s) ORCID Number
Michael Vouche http://orcid.org/0000-0002-7260-6074
Thierry Degrez http://orcid.org/0000-0003-3600-1761
Fikri Bouazza http://orcid.org/0000-0002-1636-2888
Philippe Delatte http://orcid.org/0000-0003-2757-674X
Maria Gomez Galdon http://orcid.org/0000-0001-6943-0402
Alain Hendlisz http://orcid.org/0000-0003-2122-1948
Patrick Flamen http://orcid.org/0000-0003-2193-6599
Vincent Donckier http://orcid.org/0000-0003-1457-2520
Funding Agency and Grant Number
Corresponding Author Vincent Donckier, MD, PhD, Professor, Department of Abdominal Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Rue Héger-Bordet, 1, Brussels 1000, Belgium. vincent.donckier@bordet.be
Key Words Hepatocellular carcinoma; Cirrhosis; Resectability; Radioembolization; Sequential; Efficacy; Safety
Core Tip Preoperative radioembolization may improve resectability of hepatocellular carcinoma in cirrhotic patient, inducing tumor downsizing, atrophy of radio-embolized sector and regeneration of non-embolized liver. We describe a patient with a segment IV hepatocellular carcinoma where the presence of two separated left hepatic arteries permitted to deliver sequentially high-dose 90Yttrium to the tumor and lower dose to future resected liver, allowing uneventful left hepatectomy 3 months later. This observation suggests that, when different arterial accesses exist to tumor and future resected non-tumor liver, sequential radioembolization with different radiation doses could represent a new preoperative strategy, optimizing the tumoricidal effect while minimizing the risk of radiation-induced liver damage.
Publish Date 2017-12-27 10:31
Citation Vouche M, Degrez T, Bouazza F, Delatte P, Gomez Galdon M, Hendlisz A, Flamen P, Donckier V. Sequential tumor-directed and lobar radioembolization before major hepatectomy for hepatocellular carcinoma. World J Hepatol 2017; 9(36): 1372-1377 Available from: URL: http://www.wjgnet.com/1948-5182/full/v9/i36/1372.htm DOI: http://dx.doi.org/10.4254/wjh.v9.i36.1372
URL http://www.wjgnet.com/1948-5182/full/v9/i36/1372.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i36.1372
Full Article (PDF) WJH-9-1372.pdf
Full Article (Word) WJH-9-1372.doc
Manuscript File 36026-Review.docx
Answering Reviewers 36026-Answering reviewers.pdf
Audio Core Tip 36026-Audio core tip.wav
Conflict-of-Interest Disclosure Form 36026-Conflict-of-interest statement.pdf
Copyright License Agreement 36026-Copyright license agreement.pdf
Peer-review Report 36026-Peer-review(s).pdf
Scientific Misconduct Check 36026-Scientific misconduct check.pdf
Scientific Editor Work List 36026-Scientific editor work list.pdf