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Articles Published Processes
1/26/2018 2:31:05 AM | Browse: 982 | Download: 1147
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Received |
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2017-09-11 15:35 |
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Peer-Review Started |
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2017-09-12 05:46 |
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To Make the First Decision |
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2017-10-18 06:53 |
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Return for Revision |
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2017-10-23 12:08 |
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Revised |
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2017-11-22 00:14 |
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Second Decision |
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2017-11-27 09:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-27 20:32 |
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Articles in Press |
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2017-11-27 20:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-22 08:51 |
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Publish the Manuscript Online |
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2018-01-26 02:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Roberto Rodriguez-Echevarria, Jose Macias-Barragan, Marcela Parra-Vargas, Judith Rebeca Davila-Rodriguez, Eduardo Amezcua-Galvez and Juan Armendariz-Borunda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Juan Armendariz-Borunda, PhD, Professor, Senior Scientist, Department of Molecular Biology and Genomics, University of Guadalajara, 950 Sierra Mojada St., Guadalajara 44340, Mexico. armendbo@cucs.udg.mx |
| Key Words |
Nonalcoholic fatty liver disease; Polyunsaturated fatty acids; 18-hydroxy-eicosa¬pentaenoic acid; 17-hydroxy-docosahexaenoic acid; Obesity |
| Core Tip |
Our study aimed to prove the efficacy of hydroxy-fatty acids 18-hydroxy-eicosapentaenoic acid and 17-hydroxy-docosahexaenoic acid (17-HDHA) in an obesity/nonalcoholic fatty liver disease (NAFLD) model in mice. We determined the effect of these molecules on histological morphology as well as in protein levels of key nuclear receptors and serum hormones, incretins and adipokines as these parameters are altered in NAFLD. We reported an effect by these hydroxy-fatty acids on the most relevant target proteins involved in this pathological process (PPAR /). Also, we demonstrated that diet switch regimen is a selective treatment control as most NAFLD markers and histological alterations were ameliorated by this intervention. |
| Publish Date |
2018-01-26 02:31 |
| Citation |
Rodriguez-Echevarria R, Macias-Barragan J, Parra-Vargas M, Davila-Rodriguez JR, Amezcua-Galvez E, Armendariz-Borunda J. Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice. World J Gastroenterol 2018; 24(4): 461-474 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i4/461.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i4.461 |
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