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Articles Published Processes
1/26/2018 8:09:36 AM | Browse: 1691 | Download: 3013
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Received |
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2017-10-13 02:54 |
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Peer-Review Started |
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2017-10-13 07:45 |
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First Decision by Editorial Office Director |
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2017-11-06 19:41 |
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Return for Revision |
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2017-11-07 06:32 |
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Revised |
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2017-11-20 22:50 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-11-28 08:21 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-12-06 21:23 |
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Articles in Press |
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2017-12-06 21:23 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-21 02:14 |
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Publish the Manuscript Online |
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2018-01-26 08:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
David Haldrup, Sara Heebøll, Karen Louise Thomsen, Kasper Jarlhelt Andersen, Michelle Meier, Frank Viborg Mortensen, Jens Randel Nyengaard, Stephen Hamilton-Dutoit and Henning Grønbæk |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
David Haldrup, MD, Doctor, Doctor, Department of Gastroenterology and Hepatology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C DK-8000, Denmark. davihald@rm.dk |
| Key Words |
Rat; Non-alcoholic fatty liver; Non-alcoholic steatohepatitis; Liver regeneration; Hepatectomy; Ki-67; Gene expression |
| Core Tip |
Liver regeneration capacity has been studied in different animal models of non-alcoholic steatohepatitis. This study is the first to use a high fat high cholesterol model which mimic the pathogenesis of human non-alcoholic steatohepatitis better than previous animal models. Liver regeneration capacity was evaluated using: (1) The total number of Ki-67 positive hepatocytes in the caudate lobe, evaluated in a stereology based design; (2) the regenerated protein content to describe the regenerated liver mass; and (3) the plasma concentration of coagulation factors as a marker of liver function. We found a preserved liver regeneration capacity in rats with non-alcoholic steatohepatitis, adding important knowledge to the subject. |
| Publish Date |
2018-01-26 08:09 |
| Citation |
Haldrup D, Heebøll S, Thomsen KL, Andersen KJ, Meier M, Mortensen FV, Nyengaard JR, Hamilton-Dutoit S, Grønbæk H. Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis. World J Hepatol 2018; 10(1): 8-21 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i1/8.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i1.8 |
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